内容紹介
A Case of Rhabdomyolysis Related to SOX Therapy for Liver Metastasis of Gastric Cancer
Summary
We report a case of rhabdomyolysis related to S-1 plus oxaliplatin(SOX)therapy for liver metastasis of gastric cancer. A 76-year-old man who had received SOX therapy for metastatic gastric cancer was admitted to our hospital for a chief complaint of fatigue and weakness. He diagnosed with rhabdomyolysis related to SOX therapy because of his symptoms and because his laboratory studies showed significant elevation of his serum creatine kinase(CK)level. The symptoms disappeared and the CK level normalized following large-volume transfusions. Rhabdomyolysis following SOX therapy is a very rare, but severe adverse event. This is the first detailed case report of rhabdomyolysis related to SOX therapy.
要旨
胃癌術後肝転移再発に対しS-1+oxaliplatin併用(SOX)療法施行中に横紋筋融解症を発症した1例を経験した。症例は76歳,男性。脱力感,倦怠感を主訴に救急受診し,症状と血清creatine kinaseの異常高値から横紋筋融解症と診断された。急性腎不全およびショックに至り,集中治療室での治療を要したものの,大量補液により横紋筋融解症は軽快した。原因としてSOX療法の関与が疑われたため化学療法は中止とし,転移性肝癌に対し肝切除術を施行した。SOX療法が原因と考えられた横紋筋融解症の報告は本症例が初めてであり,文献的考察を加え報告する。
目次
Summary
We report a case of rhabdomyolysis related to S-1 plus oxaliplatin(SOX)therapy for liver metastasis of gastric cancer. A 76-year-old man who had received SOX therapy for metastatic gastric cancer was admitted to our hospital for a chief complaint of fatigue and weakness. He diagnosed with rhabdomyolysis related to SOX therapy because of his symptoms and because his laboratory studies showed significant elevation of his serum creatine kinase(CK)level. The symptoms disappeared and the CK level normalized following large-volume transfusions. Rhabdomyolysis following SOX therapy is a very rare, but severe adverse event. This is the first detailed case report of rhabdomyolysis related to SOX therapy.
要旨
胃癌術後肝転移再発に対しS-1+oxaliplatin併用(SOX)療法施行中に横紋筋融解症を発症した1例を経験した。症例は76歳,男性。脱力感,倦怠感を主訴に救急受診し,症状と血清creatine kinaseの異常高値から横紋筋融解症と診断された。急性腎不全およびショックに至り,集中治療室での治療を要したものの,大量補液により横紋筋融解症は軽快した。原因としてSOX療法の関与が疑われたため化学療法は中止とし,転移性肝癌に対し肝切除術を施行した。SOX療法が原因と考えられた横紋筋融解症の報告は本症例が初めてであり,文献的考察を加え報告する。