内容紹介
Nonalcoholic fatty liver disease(NAFLD)は日本では最もポピュラーな肝疾患である。一部のNAFLD患者、特にnonalcoholic steatohepatitis(NASH)は、肝硬変に進行し門脈圧亢進症、肝不全、肝細胞癌で死亡する。しかしNAFLDの長期予後は完全には解明されていない。最近、Angulo PらはNASHの他の組織学的な所見ではなく、線維化のみが全生存率に関係していると報告した、NASHの診断基準を再考すべき時が来ている。
Nonalcoholic fatty liver disease (NAFLD) represents the most common liver condition in Japan.Some patients with NAFLD,especially nonalcoholic steatohepatitis (NASH),may develop cirrhosis and die from complications of portal hypertension,liver failure,and hepatocellular cancer.However,the long〜term prognosis of patients with NAFLD remains incompletely elucidated.Recently, Angulo P reported that
fibrosis stage,but no other histologic features of steatohepatitis,were associated independently with longterm overall mortality.It is time to reconsider the diagnostic criteria of NASH.
目次
Nonalcoholic fatty liver disease (NAFLD) represents the most common liver condition in Japan.Some patients with NAFLD,especially nonalcoholic steatohepatitis (NASH),may develop cirrhosis and die from complications of portal hypertension,liver failure,and hepatocellular cancer.However,the long〜term prognosis of patients with NAFLD remains incompletely elucidated.Recently, Angulo P reported that
fibrosis stage,but no other histologic features of steatohepatitis,were associated independently with longterm overall mortality.It is time to reconsider the diagnostic criteria of NASH.