内容紹介
Efficacy of GC Therapy for the Patient of iTNBC with Resistance to TAC Therapy
Summary
We report a case of TNBC treated effectively with a platinum-based regimen after developing resistance to anthracycline and taxane-based neoadjuvant chemotherapy(NAC). A 59-year-old woman with a right breast mass and high fever visited our clinic and was diagnosed as having inflammatory triple negative breast cancer(iTNBC). She was treated with NAC of docetaxel, doxorubicin, and cyclophosphamide(TAC)using pegfilgrastim. After 5 courses of TAC, the therapy failed and the disease progressed. Thus, a combination regimen of gemcitabine and carboplatin(GC)was administered. The treatment was successful, and the patient underwent a curative operation after 6 courses of the GC therapy.
要旨
症例は59歳,女性。右乳房腫瘤と発熱を主訴に受診した。針生検にてトリプルネガティブ(TN)炎症性乳癌と診断し,ペグフィルグラスチム併用下にドセタキセル,ドキソルビシン,シクロフォスファミド同時併用のTAC療法を術前化学療法として開始した。一時奏効を認めたものの抵抗性に転じ,ゲムシタビン,カルボプラチン併用のGC療法に変更した結果,再度奏効し根治手術が可能となった。アンスラサイクリン・タキサンに抵抗性を示すTN乳癌に対し,プラチナ系抗悪性腫瘍剤への変更が有効である可能性が示唆された。
目次
Summary
We report a case of TNBC treated effectively with a platinum-based regimen after developing resistance to anthracycline and taxane-based neoadjuvant chemotherapy(NAC). A 59-year-old woman with a right breast mass and high fever visited our clinic and was diagnosed as having inflammatory triple negative breast cancer(iTNBC). She was treated with NAC of docetaxel, doxorubicin, and cyclophosphamide(TAC)using pegfilgrastim. After 5 courses of TAC, the therapy failed and the disease progressed. Thus, a combination regimen of gemcitabine and carboplatin(GC)was administered. The treatment was successful, and the patient underwent a curative operation after 6 courses of the GC therapy.
要旨
症例は59歳,女性。右乳房腫瘤と発熱を主訴に受診した。針生検にてトリプルネガティブ(TN)炎症性乳癌と診断し,ペグフィルグラスチム併用下にドセタキセル,ドキソルビシン,シクロフォスファミド同時併用のTAC療法を術前化学療法として開始した。一時奏効を認めたものの抵抗性に転じ,ゲムシタビン,カルボプラチン併用のGC療法に変更した結果,再度奏効し根治手術が可能となった。アンスラサイクリン・タキサンに抵抗性を示すTN乳癌に対し,プラチナ系抗悪性腫瘍剤への変更が有効である可能性が示唆された。