内容紹介
A Case of Pneumocystis Pneumonia during Adjuvant Dose-Dense Chemotherapy for Breast Cancer
Summary
A 47-year-old woman received adjuvant chemotherapy for breast cancer. On the 13th day of 4 courses of dose-dense AC therapy, she developed a fever. She was orally administered an antibiotic for febrile neutropenia treatment. She showed no improvement of symptoms and gradually presented with new symptoms, including a non-productive cough and dyspnea. After admission, she underwent a further examination, and was provided a diagnosis of pneumocystis pneumonia. It is reported that patients receiving chemotherapy for solid tumors are less likely to develop opportunistic infections. However, patients receiving dose-dense chemotherapy may have a higher risk for developing opportunistic infections than those receiving conventional chemotherapy.
要旨
症例は47歳,女性。乳癌術後補助化学療法dose-dense AC 4コース目day 13に発熱があり,FNに準じて治療するも改善がなかった。しだいに呼吸困難・咳嗽が出現してきたため,入院後,精査の結果,ニューモシスチス肺炎の診断であった。固形腫瘍における化学療法では日和見感染の可能性は低いとされているが,従来の化学療法スケジュールの3週毎投与よりdose-dense投与は日和見感染の頻度が高い可能性がある。
目次
Summary
A 47-year-old woman received adjuvant chemotherapy for breast cancer. On the 13th day of 4 courses of dose-dense AC therapy, she developed a fever. She was orally administered an antibiotic for febrile neutropenia treatment. She showed no improvement of symptoms and gradually presented with new symptoms, including a non-productive cough and dyspnea. After admission, she underwent a further examination, and was provided a diagnosis of pneumocystis pneumonia. It is reported that patients receiving chemotherapy for solid tumors are less likely to develop opportunistic infections. However, patients receiving dose-dense chemotherapy may have a higher risk for developing opportunistic infections than those receiving conventional chemotherapy.
要旨
症例は47歳,女性。乳癌術後補助化学療法dose-dense AC 4コース目day 13に発熱があり,FNに準じて治療するも改善がなかった。しだいに呼吸困難・咳嗽が出現してきたため,入院後,精査の結果,ニューモシスチス肺炎の診断であった。固形腫瘍における化学療法では日和見感染の可能性は低いとされているが,従来の化学療法スケジュールの3週毎投与よりdose-dense投与は日和見感染の頻度が高い可能性がある。