内容紹介
Successful Treatment with 5-fluorouracil and Levofolinate Calcium in Advanced Gastric Cancer Patient with Disseminated Intravascular Coagulation
Summary
A 32-year-old woman was found to have a gastric adenocarcinoma with multiple bone metastases. Chemotherapy in the first, second and third-line was not effective. Blood examinations showed disseminated intravascular coagulation(DIC)at the end of the second-line chemotherapy. The fourth-line chemotherapy, infusional 5-fluorouracil and levofolinate calcium was performed. This resulted in a good response for DIC. This palliative therapy was effective and safety.
要旨
播種性血管内凝固症候群(disseminated intravascular coagulation: DIC)は基礎疾患の存在下に全身性持続性の著しい凝固活性化を来し,細小血管内に微小血栓が多発する重篤な病態である。胃癌にもまれに合併し,その予後は著しく不良であることが知られている。症例: 32歳,女性。T2(ss),N1,H0,P0,M0,CY1,Stage Ⅳの診断で化学療法中に多発骨転移,DICを認めた。Methotrexate+5-fluorouracil(5-FU)療法を施行したが改善なく,5-FU+levofolinate calcium(l-LV)療法を施行しDICを離脱できた。結語: 5-FU+l-LV療法は胃癌癌性DICに有効なレジメンの可能性が示唆された。
目次
癌と化学療法 TOPへ
癌と化学療法 44巻10号 2017年10月号トップへ
【症例】
▶Successful Treatment with 5-fluorouracil and Levofolinate Calcium in Advanced Gastric Cancer Patient with Disseminated Intravascular Coagulation 武藤 理ほか
Summary
A 32-year-old woman was found to have a gastric adenocarcinoma with multiple bone metastases. Chemotherapy in the first, second and third-line was not effective. Blood examinations showed disseminated intravascular coagulation(DIC)at the end of the second-line chemotherapy. The fourth-line chemotherapy, infusional 5-fluorouracil and levofolinate calcium was performed. This resulted in a good response for DIC. This palliative therapy was effective and safety.
要旨
播種性血管内凝固症候群(disseminated intravascular coagulation: DIC)は基礎疾患の存在下に全身性持続性の著しい凝固活性化を来し,細小血管内に微小血栓が多発する重篤な病態である。胃癌にもまれに合併し,その予後は著しく不良であることが知られている。症例: 32歳,女性。T2(ss),N1,H0,P0,M0,CY1,Stage Ⅳの診断で化学療法中に多発骨転移,DICを認めた。Methotrexate+5-fluorouracil(5-FU)療法を施行したが改善なく,5-FU+levofolinate calcium(l-LV)療法を施行しDICを離脱できた。結語: 5-FU+l-LV療法は胃癌癌性DICに有効なレジメンの可能性が示唆された。