内容紹介
Indoleamine 2,3-Dioxygenase Activity during Fulvestrant Therapy for Aromatase Inhibitor Resistant Metastatic Breast Cancer
Summary
We evaluated the clinical significance of indoleamine 2,3-dioxygenase(IDO)for breast cancer patients between different clinical stages and patient ages. IDO activity was measured by the tryptophan(Trp)/kynurenine(Kyn)ratio. Trp and Kyn levels were measured using high performance liquid chromatography(HPLC). Serum Trp/Kyn levels in Stage Ⅳ breast cancer patients were lower than in patients at other stages. Serum Trp/Kyn levels of breast cancer patients over the age of 70 years were lower than in patients under the age of 69 years. Within the same clinical stage, serum Trp/Kyn levels of breast cancer patients over the age of 70 years were lower than in patients under the age of 69 years. These results suggest that the immunological profile of breast cancer patients over the age of 70 years may be immunosuppressive compared to breast cancer patients under the age of 69 years.
要旨
原発性浸潤性乳管癌136例について乳癌担癌状態におけるindoleamine 2,3-dioxygenase(IDO)の発現が,同一臨床病期で年齢別にどのように変化しているか探索した。初診時に採血を行い,得られた血漿について,tryptophan(Trp)とkynurenine(Kyn)を測定し,Trp/Kyn ratioからIDOのactivityを測定した。対象とした136例の臨床病期はStageⅠ30例,StageⅡ 46例,Stage Ⅲ 26例,Stage Ⅳ 34例であった。年齢層別では30歳台12例,40歳台20例,50歳台24例,60歳台20例,70歳台24例,80歳台20例,90歳台16例であった。同一臨床病期において年齢別にTrp/Kyn ratioを比較すると70歳台以上の症例はそれ以下の症例と比較して有意にTrp/Kyn ratioが低かった。臨床病期別にみると,Stage Ⅳの症例はその他のStageに比べて有意にTrp/Kyn ratioが低かった。乳癌担癌状態で同一臨床病期において,年齢別に比較しても年齢が上昇するに従ってTrp/Kyn ratioは低下した。
目次
Summary
We evaluated the clinical significance of indoleamine 2,3-dioxygenase(IDO)for breast cancer patients between different clinical stages and patient ages. IDO activity was measured by the tryptophan(Trp)/kynurenine(Kyn)ratio. Trp and Kyn levels were measured using high performance liquid chromatography(HPLC). Serum Trp/Kyn levels in Stage Ⅳ breast cancer patients were lower than in patients at other stages. Serum Trp/Kyn levels of breast cancer patients over the age of 70 years were lower than in patients under the age of 69 years. Within the same clinical stage, serum Trp/Kyn levels of breast cancer patients over the age of 70 years were lower than in patients under the age of 69 years. These results suggest that the immunological profile of breast cancer patients over the age of 70 years may be immunosuppressive compared to breast cancer patients under the age of 69 years.
要旨
原発性浸潤性乳管癌136例について乳癌担癌状態におけるindoleamine 2,3-dioxygenase(IDO)の発現が,同一臨床病期で年齢別にどのように変化しているか探索した。初診時に採血を行い,得られた血漿について,tryptophan(Trp)とkynurenine(Kyn)を測定し,Trp/Kyn ratioからIDOのactivityを測定した。対象とした136例の臨床病期はStageⅠ30例,StageⅡ 46例,Stage Ⅲ 26例,Stage Ⅳ 34例であった。年齢層別では30歳台12例,40歳台20例,50歳台24例,60歳台20例,70歳台24例,80歳台20例,90歳台16例であった。同一臨床病期において年齢別にTrp/Kyn ratioを比較すると70歳台以上の症例はそれ以下の症例と比較して有意にTrp/Kyn ratioが低かった。臨床病期別にみると,Stage Ⅳの症例はその他のStageに比べて有意にTrp/Kyn ratioが低かった。乳癌担癌状態で同一臨床病期において,年齢別に比較しても年齢が上昇するに従ってTrp/Kyn ratioは低下した。