内容紹介
Indoleamine 2,3-Dioxygenase Activity during Letrozol Therapy for an Elderly Breast Cancer Patient
Summary
We evaluated the clinical significance of indoleamine 2,3-dioxygenase(IDO)during letrozol therapy for an elderly patient with locally advanced breast cancer. IDO activity was measured by the tryptophan(Trp)/kynurenine(Kyn)ratio. Trp and Kyn levels were measured using high performance liquid chromatography(HPLC). Serum Trp/Kyn levels of the patient before endocrine therapy were lower than those after endocrine therapy. IDO activity decreased after endocrine therapy and correlated with the number of metastatic lymph node lesions during letrozol therapy. These results suggest that measuring the Trp/Kyn ratio may be useful for evaluating immunological metastatic status during endocrine therapy in elderly patients with locally advanced breast cancer.
要旨
letrozolが長期間奏効した内分泌受容体陽性の超高齢者局所進行乳癌症例に対して,その治療経過中のindoleamine 2,3-dioxygenase(IDO)の発現程度を検討した。初診時より定期的に採血を施行し,HPLCを用いてtryptophan(Trp)とkynurenine(Kyn)を測定し,Trp/Kyn ratioからIDOのactivityを測定した。治療を開始した後,letrozolが奏効するに従ってTrp/Kyn ratioは増加していった。letrozolによる内分泌受容体陽性乳癌の治療効果判定にIDOのactivityを測定することは有用であると考えられた。
目次
Summary
We evaluated the clinical significance of indoleamine 2,3-dioxygenase(IDO)during letrozol therapy for an elderly patient with locally advanced breast cancer. IDO activity was measured by the tryptophan(Trp)/kynurenine(Kyn)ratio. Trp and Kyn levels were measured using high performance liquid chromatography(HPLC). Serum Trp/Kyn levels of the patient before endocrine therapy were lower than those after endocrine therapy. IDO activity decreased after endocrine therapy and correlated with the number of metastatic lymph node lesions during letrozol therapy. These results suggest that measuring the Trp/Kyn ratio may be useful for evaluating immunological metastatic status during endocrine therapy in elderly patients with locally advanced breast cancer.
要旨
letrozolが長期間奏効した内分泌受容体陽性の超高齢者局所進行乳癌症例に対して,その治療経過中のindoleamine 2,3-dioxygenase(IDO)の発現程度を検討した。初診時より定期的に採血を施行し,HPLCを用いてtryptophan(Trp)とkynurenine(Kyn)を測定し,Trp/Kyn ratioからIDOのactivityを測定した。治療を開始した後,letrozolが奏効するに従ってTrp/Kyn ratioは増加していった。letrozolによる内分泌受容体陽性乳癌の治療効果判定にIDOのactivityを測定することは有用であると考えられた。