内容紹介
A Prognostic Factor Based on Inflammation, Nutrition, and Immune Status for fStageⅡ/Ⅲ Colorectal Cancer
Summary
Introduction: We investigated whether the prognostic nutritional index(PNI), controlling nutritional status(CONUT), modified Glasgow prognostic score(mGPS), and the neutrophil count/lymphocyte number ratio(NLR)could be prognostic factors for fStageⅡ/Ⅲ colorectal cancer. Subjects and methods: The subjects were 115 patients with fStageⅡ/Ⅲ colorectal cancer who underwent curative resection. We studied the relationship with 3-year disease-free survival(DFS)and 5-year survival rate(OS). Results: DFS and OS were 75.6% and 84.4%, respectively, and 81.3% and 69.6% for DFS and 82.4% and 84.4% for OS were in fStageⅡ and Ⅲ, respectively. Univariate analysis of DFS showed significant differences for sex, age, PNI, and NLR, but there was no difference in PS, location, adjuvant chemotherapy, CONUT, or mGPS. In multivariate analysis, sex(male)and NLR(>2)were independent prognostic factors(p=0.006 and p=0.01, respectively). As for OS, although significant differences were recognized for sex, age, PS, PNI, NLR, and CONUT, there was no difference in location, adjuvant chemotherapy, or mGPS. In multivariate analysis, PS(≥1)and NLR(>2)were independent prognostic factors(p=0.009 and p=0.006, respectively). Conclusions: NLR(>2)was an independent prognostic factor for DFS and OS among prognostic factors based on inflammation, nutrition, and immunity in fStageⅡ/Ⅲ colorectal cancer patients.
要旨
はじめに: 小野寺式栄養指数(PNI),controlling nutritional status(CONUT),modified Glasgow prognostic score(mGPS),好中球数/リンパ球数比(NLR)がfStageⅡ/Ⅲ大腸癌における予後因子となり得るか検討した。対象・方法: 対象は治癒切除を施行したfStageⅡ/Ⅲ大腸癌患者115例である。3年無病生存率(DFS)および5年生存率(OS)との関連を検討した。結果: 全体のDFSおよびOSは各75.6%,84.4%で,fStageⅡおよびⅢではDFS各81.3%,69.6%,OS各82.4%,84.4%であった。DFSに関する単変量解析では,性別,年齢,PNI,NLRで有意差を認めたが,PS,占居部位,補助化学療法の有無,CONUT,mGPSで差はなかった。多変量解析では,性別(男性),NLR(>2)が独立した予後不良因子であった(p=0.006,p=0.01)。OSに関しては,性別,年齢,PS,PNI,NLR,CONUTで有意差を認めたが,占居部位,補助化学療法の有無,mGPSで差はなかった。多変量解析では,PS(≧1),NLR(>2)が独立した予後不良因子であった(p=0.009,p=0.006)。結論: fStageⅡ/Ⅲ大腸癌患者における炎症・栄養・免疫を基にした予後因子のうち,NLR(>2)がDFSおよびOSにおいて独立した予後不良因子であった。
目次
Summary
Introduction: We investigated whether the prognostic nutritional index(PNI), controlling nutritional status(CONUT), modified Glasgow prognostic score(mGPS), and the neutrophil count/lymphocyte number ratio(NLR)could be prognostic factors for fStageⅡ/Ⅲ colorectal cancer. Subjects and methods: The subjects were 115 patients with fStageⅡ/Ⅲ colorectal cancer who underwent curative resection. We studied the relationship with 3-year disease-free survival(DFS)and 5-year survival rate(OS). Results: DFS and OS were 75.6% and 84.4%, respectively, and 81.3% and 69.6% for DFS and 82.4% and 84.4% for OS were in fStageⅡ and Ⅲ, respectively. Univariate analysis of DFS showed significant differences for sex, age, PNI, and NLR, but there was no difference in PS, location, adjuvant chemotherapy, CONUT, or mGPS. In multivariate analysis, sex(male)and NLR(>2)were independent prognostic factors(p=0.006 and p=0.01, respectively). As for OS, although significant differences were recognized for sex, age, PS, PNI, NLR, and CONUT, there was no difference in location, adjuvant chemotherapy, or mGPS. In multivariate analysis, PS(≥1)and NLR(>2)were independent prognostic factors(p=0.009 and p=0.006, respectively). Conclusions: NLR(>2)was an independent prognostic factor for DFS and OS among prognostic factors based on inflammation, nutrition, and immunity in fStageⅡ/Ⅲ colorectal cancer patients.
要旨
はじめに: 小野寺式栄養指数(PNI),controlling nutritional status(CONUT),modified Glasgow prognostic score(mGPS),好中球数/リンパ球数比(NLR)がfStageⅡ/Ⅲ大腸癌における予後因子となり得るか検討した。対象・方法: 対象は治癒切除を施行したfStageⅡ/Ⅲ大腸癌患者115例である。3年無病生存率(DFS)および5年生存率(OS)との関連を検討した。結果: 全体のDFSおよびOSは各75.6%,84.4%で,fStageⅡおよびⅢではDFS各81.3%,69.6%,OS各82.4%,84.4%であった。DFSに関する単変量解析では,性別,年齢,PNI,NLRで有意差を認めたが,PS,占居部位,補助化学療法の有無,CONUT,mGPSで差はなかった。多変量解析では,性別(男性),NLR(>2)が独立した予後不良因子であった(p=0.006,p=0.01)。OSに関しては,性別,年齢,PS,PNI,NLR,CONUTで有意差を認めたが,占居部位,補助化学療法の有無,mGPSで差はなかった。多変量解析では,PS(≧1),NLR(>2)が独立した予後不良因子であった(p=0.009,p=0.006)。結論: fStageⅡ/Ⅲ大腸癌患者における炎症・栄養・免疫を基にした予後因子のうち,NLR(>2)がDFSおよびOSにおいて独立した予後不良因子であった。