内容紹介
Clinical Evaluation of Indoleamine 2, 3-Dioxygenase in the Serum of Patients with Locally Advanced Breast Cancer during Mohs Paste Treatment
Summary
Locally advanced breast cancer lesions often compromise patients' quality of life(QOL). Mohs paste is a histopathological fixative with zinc chloride as the main ingredient. It is applied when performing chemosurgery for skin tumors. In recent years, this paste has reportedly been very effective for the control of various symptoms of skin metastases in inoperable advanced cancers, such as pungent odor and hemorrhage, in the field of palliative care. We evaluated the clinical significance of indoleamine 2, 3-dioxygenase(IDO)in the serum of patients with locally advanced breast cancer during Mohs paste treatment. IDO activity was measured by the tryptophan(Trp)/kynurenine(Kyn)ratio. Trp and Kyn levels were measured using high performance liquid chromatography(HPLC). We collected serum samples from 3 locally advanced breast cancer cases: once in the pre-treatment phase, 2 times in the post-treatment phase, and 5 times in the post-treatment phase. Then, we measured the Trp/Kyn ratio and CRP in these samples during Mohs paste treatment. There were no significant differences in serum Trp/Kyn ratios between the phases, but serum CRP values decreased after Mohs paste treatment. These results suggest that Mohs paste treatment for locally advanced breast cancer lesions may be useful in enhancing patients' QOL without immunosuppression.
要旨
皮膚浸潤を伴う局所進行乳癌は,出血・滲出液・感染による悪臭を呈するため局所コントロールに難渋することが多いが,Mohsペーストはこうした局所進行乳癌に有用であることが多数報告されている。今回われわれは,皮膚潰瘍を伴う病理組織学的に診断された局所進行乳癌のうちMohsペースト外用で局所の治療をした3例を対象に,末梢血中のtryptophan(Trp)/kynurenine(Kyn)ratioおよびCRP値を測定し,Mohsペーストが免疫にどのように影響を与えるかを検証した。治療開始前,2回終了時,5回終了時(1週間後)に採血し,血液中のTrp/Kyn値,CRP値を測定した。Trp/Kyn ratioからIDOのactivityを測定した。結果として,Trp/Kyn ratioは治療開始前,2回終了時,5回終了時ともに有意な変化は認めなかった。CRP値はMohsペースト治療開始前,2回終了時,5回終了時と回数を追うに従って有意に低下した。
目次
Summary
Locally advanced breast cancer lesions often compromise patients' quality of life(QOL). Mohs paste is a histopathological fixative with zinc chloride as the main ingredient. It is applied when performing chemosurgery for skin tumors. In recent years, this paste has reportedly been very effective for the control of various symptoms of skin metastases in inoperable advanced cancers, such as pungent odor and hemorrhage, in the field of palliative care. We evaluated the clinical significance of indoleamine 2, 3-dioxygenase(IDO)in the serum of patients with locally advanced breast cancer during Mohs paste treatment. IDO activity was measured by the tryptophan(Trp)/kynurenine(Kyn)ratio. Trp and Kyn levels were measured using high performance liquid chromatography(HPLC). We collected serum samples from 3 locally advanced breast cancer cases: once in the pre-treatment phase, 2 times in the post-treatment phase, and 5 times in the post-treatment phase. Then, we measured the Trp/Kyn ratio and CRP in these samples during Mohs paste treatment. There were no significant differences in serum Trp/Kyn ratios between the phases, but serum CRP values decreased after Mohs paste treatment. These results suggest that Mohs paste treatment for locally advanced breast cancer lesions may be useful in enhancing patients' QOL without immunosuppression.
要旨
皮膚浸潤を伴う局所進行乳癌は,出血・滲出液・感染による悪臭を呈するため局所コントロールに難渋することが多いが,Mohsペーストはこうした局所進行乳癌に有用であることが多数報告されている。今回われわれは,皮膚潰瘍を伴う病理組織学的に診断された局所進行乳癌のうちMohsペースト外用で局所の治療をした3例を対象に,末梢血中のtryptophan(Trp)/kynurenine(Kyn)ratioおよびCRP値を測定し,Mohsペーストが免疫にどのように影響を与えるかを検証した。治療開始前,2回終了時,5回終了時(1週間後)に採血し,血液中のTrp/Kyn値,CRP値を測定した。Trp/Kyn ratioからIDOのactivityを測定した。結果として,Trp/Kyn ratioは治療開始前,2回終了時,5回終了時ともに有意な変化は認めなかった。CRP値はMohsペースト治療開始前,2回終了時,5回終了時と回数を追うに従って有意に低下した。