内容紹介
Three Cases of High-Grade Malignant Cancer of Unknown Primary with a Long-Term Survival
Summary
We report 3 unusual cases of cancer of unknown primary(CUP)with a long-term survival after chemotherapy. A 56-year-old man was diagnosed as having CUP with invasion of an enlarged carcinoma 20 cm in size to the pancreas and peritoneal dissemination. He received chemotherapy with paclitaxel, carboplatin, and gemcitabine. After the chemotherapy, CT scan and PET-CT revealed no evidence of disease, so tumor resection was performed. The subsequent pathological findings revealed no cancer and a complete pathological response. The patient is currently alive 4 years after the first surgery, without evidence of recurrence and adjuvant chemotherapy. A 60-year-old man was diagnosed as having CUP with an undifferentiated carcinoma and lymph node metastasis. He received chemotherapy with paclitaxel, carboplatin, and gemcitabine. However, unanticipated adverse events(finger ulcer)occurred. Thus, the chemotherapy was changed to paclitaxel, carboplatin, and etoposide. The patient is currently alive 4.2 years after the first chemotherapy, without evidence of recurrence. A 59-year-old man was diagnosed as having CUP with neuroendocrine carcinoma(NEC)and lymph node metastasis. He received chemotherapy with irinotecan and cisplatin. The lymph node metastases disappeared, but bone metastasis was found. The chemotherapy was changed to paclitaxel, carboplatin, and etoposide. The patient is currently alive 3.5 years after the first chemotherapy, without evidence of recurrence. We report 3 rare cases of high-grade malignant CUP with complete pathological response, partial response, stable disease, and long-term survival after chemotherapy.
要旨
化学療法にて3年以上の長期生存を得ている予後不良群の原発不明癌(cancer of unknown primary: CUP)の3症例を報告する。1症例目は膵頭十二指腸のCUPであり,化学療法後にcCR,膵頭十二指腸切除後にpCRを得て4年間生存している。2症例目は未分化癌のCUPであり,化学療法後にPRを得たが有害事象を認め,二次,三次治療を施行し,SDにて4.2年間生存している。3症例目は低分化型神経内分泌性癌のCUPであり,化学療法後にPRを得たが骨転移を認め二次治療を施行し,SDにて3.5年間生存している。
目次
Summary
We report 3 unusual cases of cancer of unknown primary(CUP)with a long-term survival after chemotherapy. A 56-year-old man was diagnosed as having CUP with invasion of an enlarged carcinoma 20 cm in size to the pancreas and peritoneal dissemination. He received chemotherapy with paclitaxel, carboplatin, and gemcitabine. After the chemotherapy, CT scan and PET-CT revealed no evidence of disease, so tumor resection was performed. The subsequent pathological findings revealed no cancer and a complete pathological response. The patient is currently alive 4 years after the first surgery, without evidence of recurrence and adjuvant chemotherapy. A 60-year-old man was diagnosed as having CUP with an undifferentiated carcinoma and lymph node metastasis. He received chemotherapy with paclitaxel, carboplatin, and gemcitabine. However, unanticipated adverse events(finger ulcer)occurred. Thus, the chemotherapy was changed to paclitaxel, carboplatin, and etoposide. The patient is currently alive 4.2 years after the first chemotherapy, without evidence of recurrence. A 59-year-old man was diagnosed as having CUP with neuroendocrine carcinoma(NEC)and lymph node metastasis. He received chemotherapy with irinotecan and cisplatin. The lymph node metastases disappeared, but bone metastasis was found. The chemotherapy was changed to paclitaxel, carboplatin, and etoposide. The patient is currently alive 3.5 years after the first chemotherapy, without evidence of recurrence. We report 3 rare cases of high-grade malignant CUP with complete pathological response, partial response, stable disease, and long-term survival after chemotherapy.
要旨
化学療法にて3年以上の長期生存を得ている予後不良群の原発不明癌(cancer of unknown primary: CUP)の3症例を報告する。1症例目は膵頭十二指腸のCUPであり,化学療法後にcCR,膵頭十二指腸切除後にpCRを得て4年間生存している。2症例目は未分化癌のCUPであり,化学療法後にPRを得たが有害事象を認め,二次,三次治療を施行し,SDにて4.2年間生存している。3症例目は低分化型神経内分泌性癌のCUPであり,化学療法後にPRを得たが骨転移を認め二次治療を施行し,SDにて3.5年間生存している。