内容紹介
A Case of Advanced Gastric Cancer Responding to Neoadjuvant Chemotherapy with Docetaxel, Cisplatin, and 5-Fluorouracil, Leading to a Pathological Complete Response
Summary
We report a 72-year-old woman who was initially diagnosed with locally advanced gastric cancer with involvement of the esophagus and pancreas. She received 3 courses of neoadjuvant chemotherapy(NAC)with docetaxel, cisplatin, and 5-fluorouracil(the DCF regimen)and achieved an excellent response. She underwent total gastrectomy with distal pancreatectomy, splenectomy, and D2 lymphadenectomy. Histological examination confirmed a pathological complete response. NAC chemotherapy can down stage/down size the disease and allow some patients to undergo curative radical surgery.
要旨
症例は72歳,女性。食物つかえ感の精査で胃癌と診断され,当科に紹介受診した。cT4bN2M0,cStage ⅢCの食道浸潤,膵浸潤を伴う胃癌と診断し,neoadjuvant chemotherapy(NAC)の方針とした。docetaxel,cisplatin,5-fluorouracil(DCF)療法3コース施行したところ原発巣・転移リンパ節ともに縮小したため,膵体尾部脾合併切除を伴う胃全摘術(D2)を施行し,病理組織学的にはpathological complete response(pCR)と診断された。
目次
Summary
We report a 72-year-old woman who was initially diagnosed with locally advanced gastric cancer with involvement of the esophagus and pancreas. She received 3 courses of neoadjuvant chemotherapy(NAC)with docetaxel, cisplatin, and 5-fluorouracil(the DCF regimen)and achieved an excellent response. She underwent total gastrectomy with distal pancreatectomy, splenectomy, and D2 lymphadenectomy. Histological examination confirmed a pathological complete response. NAC chemotherapy can down stage/down size the disease and allow some patients to undergo curative radical surgery.
要旨
症例は72歳,女性。食物つかえ感の精査で胃癌と診断され,当科に紹介受診した。cT4bN2M0,cStage ⅢCの食道浸潤,膵浸潤を伴う胃癌と診断し,neoadjuvant chemotherapy(NAC)の方針とした。docetaxel,cisplatin,5-fluorouracil(DCF)療法3コース施行したところ原発巣・転移リンパ節ともに縮小したため,膵体尾部脾合併切除を伴う胃全摘術(D2)を施行し,病理組織学的にはpathological complete response(pCR)と診断された。