内容紹介
A Case of Triple Negative Spindle Cell Carcinoma of the Breast and Improved Quality of Life Following Irinotecan Chemotherapy
Summary
We report a case of triple negative spindle cell carcinoma of the breast, responsive to irinotecan chemotherapy. A 49-year old woman who had a tumor in the chest wall with a skin ulcer visited our hospital. After being diagnosed with triple negative spindle cell carcinoma of the breast, she underwent surgery, adjuvant chemotherapy, and radiation at the other hospital. Fourteen months after the surgery, she developed an ipsilateral breast tumor as a result of local recurrence. Since eribulin and paclitaxel plus bevacizumab chemotherapies were not effective, she was transferred to our hospital, and we administered irinotecan as third-line chemotherapy. Skin lesions and effusion were reduced and her quality of life improved for 4 months.
要旨
紡錘細胞癌はまれな特殊型乳癌で,有効な薬物療法の報告は乏しい。胸壁・腋窩に局所再発し皮膚潰瘍を形成した乳腺原発トリプルネガティブ型紡錘細胞癌症例に対して,irinotecan化学療法により皮膚潰瘍を縮小させQOLを改善できたので報告する。症例は49歳,女性。他院で右乳腺原発紡錐細胞癌と診断され,手術,術後補助化学療法,残存乳房への放射線療法を受けたが,術後14か月で右胸壁に局所再発した。eribulin,次いでpaclitaxel+bevacizumab投与を行ったが増悪し,腋窩に拡がって皮膚潰瘍を形成し当院に転院した。三次治療のirinotecan投与により皮膚潰瘍は縮小,滲出液はほぼ消失し,4か月間QOLを改善・維持できた。
目次
Summary
We report a case of triple negative spindle cell carcinoma of the breast, responsive to irinotecan chemotherapy. A 49-year old woman who had a tumor in the chest wall with a skin ulcer visited our hospital. After being diagnosed with triple negative spindle cell carcinoma of the breast, she underwent surgery, adjuvant chemotherapy, and radiation at the other hospital. Fourteen months after the surgery, she developed an ipsilateral breast tumor as a result of local recurrence. Since eribulin and paclitaxel plus bevacizumab chemotherapies were not effective, she was transferred to our hospital, and we administered irinotecan as third-line chemotherapy. Skin lesions and effusion were reduced and her quality of life improved for 4 months.
要旨
紡錘細胞癌はまれな特殊型乳癌で,有効な薬物療法の報告は乏しい。胸壁・腋窩に局所再発し皮膚潰瘍を形成した乳腺原発トリプルネガティブ型紡錘細胞癌症例に対して,irinotecan化学療法により皮膚潰瘍を縮小させQOLを改善できたので報告する。症例は49歳,女性。他院で右乳腺原発紡錐細胞癌と診断され,手術,術後補助化学療法,残存乳房への放射線療法を受けたが,術後14か月で右胸壁に局所再発した。eribulin,次いでpaclitaxel+bevacizumab投与を行ったが増悪し,腋窩に拡がって皮膚潰瘍を形成し当院に転院した。三次治療のirinotecan投与により皮膚潰瘍は縮小,滲出液はほぼ消失し,4か月間QOLを改善・維持できた。