内容紹介
Secondary Dementia Due to Leptomeningeal Metastasis of Breast Cancer Improved by Whole Brain Radiation
Summary
A 62-year-old woman received chemotherapy for breast cancer with bone metastasis and malignant pleural and pericardial effusion. She was examined by imaging for progressive cognitive impairment and headache. Enhanced MRI findings showed multiple solid tumors on brain surface, and brain perfusion scintigraphy showed blood flow decrease in both parietal lobes. She was diagnosed with secondary dementia due to leptomeningeal metastases of breast cancer, and whole brain external irradiation was performed(30 Gy/15 Fr). After treatment, multiple tumors were decreased in size and her cognitive impairment was improved.
要旨
症例は62歳,女性。乳癌骨転移,癌性胸水・心囊水に対して化学療法中に記銘力障害と頭痛が出現した。造影MRI検査で脳表に多発する腫瘤があり,脳血流シンチグラフィでは両側頭頂葉の血流低下も認め,乳癌による髄膜癌腫症および続発性認知症と診断した。全脳照射(30 Gy/15 Fr)によって多発腫瘍は縮小し,2か月後には記銘力障害も著明に改善した。
目次
Summary
A 62-year-old woman received chemotherapy for breast cancer with bone metastasis and malignant pleural and pericardial effusion. She was examined by imaging for progressive cognitive impairment and headache. Enhanced MRI findings showed multiple solid tumors on brain surface, and brain perfusion scintigraphy showed blood flow decrease in both parietal lobes. She was diagnosed with secondary dementia due to leptomeningeal metastases of breast cancer, and whole brain external irradiation was performed(30 Gy/15 Fr). After treatment, multiple tumors were decreased in size and her cognitive impairment was improved.
要旨
症例は62歳,女性。乳癌骨転移,癌性胸水・心囊水に対して化学療法中に記銘力障害と頭痛が出現した。造影MRI検査で脳表に多発する腫瘤があり,脳血流シンチグラフィでは両側頭頂葉の血流低下も認め,乳癌による髄膜癌腫症および続発性認知症と診断した。全脳照射(30 Gy/15 Fr)によって多発腫瘍は縮小し,2か月後には記銘力障害も著明に改善した。