内容紹介
The Risk Factors of Cancer Chemotherapy in Elderly Patients
Summary
The aging rate in Japan is the highest in the world, and it is entering a very aging society that has never happened before. The first cause of death is a malignant neoplasm, and opportunities of the treatment for elderly cancer patients are rapidly increasing. The elderly have increased chronic diseases and complications with aging, and the adverse event in medication therapy also increases. Also, the form of medical provision is diversified, home medical care and nursing care are recommended. Therefore, it is important to appreciate the various aspects including psychophysiological, living, social aspects in addition to changes in physical function caused by aging and appropriately evaluate them, for selecting treatment methods in elderly cancer patients. Geriatric assessment(GA)is recommended for this evaluation, and it is expected to contribute to improvement of treatment outcome and quality of life(QOL). In this article, we will outline the role of aged general comprehensive functional evaluation in elderly cancer treatment and the problems of chemotherapy in the elderly.
要旨
わが国の高齢化率は世界で最も高く,まれにみる超高齢社会を迎えている。また,死亡原因の第1位は悪性新生物であり,高齢がん患者に対する治療の機会が急増している。高齢者は加齢に伴い慢性疾患や合併症の増加がみられ,薬物療法における有害事象の発生率も高くなる。医療提供の形態も多様化し在宅医療や介護も推進されている。したがって,高齢がん患者への治療方法の選択では加齢による生体機能の変化に加え精神心理面,生活面,社会面を多面的にとらえ,適切に評価することが重要である。この評価に際して高齢者機能評価(GA)の導入が推奨され,治療成績やQOLの向上への寄与が期待されている。本稿では,高齢者のがん治療における多様な背景因子を評価するGAと薬物療法について概説する。
目次
Summary
The aging rate in Japan is the highest in the world, and it is entering a very aging society that has never happened before. The first cause of death is a malignant neoplasm, and opportunities of the treatment for elderly cancer patients are rapidly increasing. The elderly have increased chronic diseases and complications with aging, and the adverse event in medication therapy also increases. Also, the form of medical provision is diversified, home medical care and nursing care are recommended. Therefore, it is important to appreciate the various aspects including psychophysiological, living, social aspects in addition to changes in physical function caused by aging and appropriately evaluate them, for selecting treatment methods in elderly cancer patients. Geriatric assessment(GA)is recommended for this evaluation, and it is expected to contribute to improvement of treatment outcome and quality of life(QOL). In this article, we will outline the role of aged general comprehensive functional evaluation in elderly cancer treatment and the problems of chemotherapy in the elderly.
要旨
わが国の高齢化率は世界で最も高く,まれにみる超高齢社会を迎えている。また,死亡原因の第1位は悪性新生物であり,高齢がん患者に対する治療の機会が急増している。高齢者は加齢に伴い慢性疾患や合併症の増加がみられ,薬物療法における有害事象の発生率も高くなる。医療提供の形態も多様化し在宅医療や介護も推進されている。したがって,高齢がん患者への治療方法の選択では加齢による生体機能の変化に加え精神心理面,生活面,社会面を多面的にとらえ,適切に評価することが重要である。この評価に際して高齢者機能評価(GA)の導入が推奨され,治療成績やQOLの向上への寄与が期待されている。本稿では,高齢者のがん治療における多様な背景因子を評価するGAと薬物療法について概説する。