内容紹介
Long-Term Capecitabine Therapy Was Successful for Locally Advanced Breast Cancer Patient―Report of a Case
Summary
For the treatment of locally advanced breast cancer, chemotherapy involving anthracycline and/or taxane-containg regimens is generally performed. However, some patients have difficult reasons for administering these intravenous chemotherapeutic agents. We experienced a case of locally advanced breast cancer patient who received long-term capecitabine therapy. This therapy was effective for this patient. A 72 year-old woman presented with a lump in her right breast. The tumor had been increasing for 15 years. The tumor had spread from the right breast to the axilla and the lateral chest, accompanied with ulceration. A core needle biopsy was performed and the pathological diagnosis was papillotubular carcinoma. We checked up her body, and there was no distant metastasis. We diagnosed the clinical stage as T4cN3aM0, stage ⅢC. She was concerned about the side effect of depilation and did not wish the standard chemotherapy. We chose capecitabine therapy. She continued capecitabine therapy and endocrine therapy. The tumor and tumor markers were decreased. The tumor size has not increased and metastatic lesions have not appeared for 5 years and a half.
要旨
局所進行乳癌に対する治療として,アンスラサイクリン系薬剤とタキサン系薬剤を中心とした化学療法が一般的に行われるが,患者によっては経静脈的な化学療法剤の投与が困難な症例も存在する。われわれは,カペシタビンの長期投与が奏効した局所進行乳癌の症例を経験したので報告する。症例は72歳,女性。15年前より右乳房腫瘤を自覚していた。増大傾向を認め,当科を受診した。右乳房から腋窩および側胸部にかけ,潰瘍形成を伴う腫瘤を認めた。針生検の結果,乳頭腺管癌(ER+,PgR+,HER2 0,Ki-67 25%)の診断であった。明らかな他臓器転移は認めず,T4cN3aM0,stage ⅢCと診断された。患者が脱毛の副作用を懸念し標準化学療法を希望しなかったため,カペシタビンを選択した。ホルモン剤を併用して投与を行ったところ,腫瘤の縮小および腫瘍マーカーの低下を認めた。治療開始から5年6か月が経過した現在,腫瘤は縮小を維持し遠隔転移は認めていない。
目次
Summary
For the treatment of locally advanced breast cancer, chemotherapy involving anthracycline and/or taxane-containg regimens is generally performed. However, some patients have difficult reasons for administering these intravenous chemotherapeutic agents. We experienced a case of locally advanced breast cancer patient who received long-term capecitabine therapy. This therapy was effective for this patient. A 72 year-old woman presented with a lump in her right breast. The tumor had been increasing for 15 years. The tumor had spread from the right breast to the axilla and the lateral chest, accompanied with ulceration. A core needle biopsy was performed and the pathological diagnosis was papillotubular carcinoma. We checked up her body, and there was no distant metastasis. We diagnosed the clinical stage as T4cN3aM0, stage ⅢC. She was concerned about the side effect of depilation and did not wish the standard chemotherapy. We chose capecitabine therapy. She continued capecitabine therapy and endocrine therapy. The tumor and tumor markers were decreased. The tumor size has not increased and metastatic lesions have not appeared for 5 years and a half.
要旨
局所進行乳癌に対する治療として,アンスラサイクリン系薬剤とタキサン系薬剤を中心とした化学療法が一般的に行われるが,患者によっては経静脈的な化学療法剤の投与が困難な症例も存在する。われわれは,カペシタビンの長期投与が奏効した局所進行乳癌の症例を経験したので報告する。症例は72歳,女性。15年前より右乳房腫瘤を自覚していた。増大傾向を認め,当科を受診した。右乳房から腋窩および側胸部にかけ,潰瘍形成を伴う腫瘤を認めた。針生検の結果,乳頭腺管癌(ER+,PgR+,HER2 0,Ki-67 25%)の診断であった。明らかな他臓器転移は認めず,T4cN3aM0,stage ⅢCと診断された。患者が脱毛の副作用を懸念し標準化学療法を希望しなかったため,カペシタビンを選択した。ホルモン剤を併用して投与を行ったところ,腫瘤の縮小および腫瘍マーカーの低下を認めた。治療開始から5年6か月が経過した現在,腫瘤は縮小を維持し遠隔転移は認めていない。