内容紹介
Chemoradiotherapy with S-1 for Recurrence Cases of Colorectal Cancer
Summary
Introduction: Although chemotherapy is the main treatment for recurrent colorectal cancer, the utility of radiotherapy as a local treatment has been widely reported. We performed chemoradiotherapy with S-1 for cases with recurrence after surgery, and the outcomes are reported herein. Materials and methods: Chemoradiotherapy with S-1 was performed in 4 cases. S-1 was administered for 2 weeks during the irradiation period, and the off period provided was 1 week. RESULTS: X-ray irradiation was performed in 2 cases and proton beam irradiation in the other 2. The progression free periods of the 2 cases receiving proton beam irradiation were 31 months and 36 months. In contrast, the progression free periods of the 2 cases given X-ray irradiation were 24 months and 21 months. Discussion: It is known that S-1 not only achieves a high anticancer effect via dihydropyrimidine dehydrogenase(DPD)inhibition, which is a major metabolic pathway of 5-FU, but also increases the radiation susceptibility of malignancies. S-1 is regarded as an ideal anticancer agent when used in combination with radiation therapy. Since the local control achieved in our 4 cases was good, chemoradiotherapy with S-1 was considered to be a useful treatment.
要旨
背景: 再発大腸癌に対する治療は化学療法が主体となるが,局所治療としての放射線治療の有用性も多く報告されている。大腸癌術後の再発症例に対して,S-1併用の化学放射線療法を施行したので治療成績を報告する。対象・方法: S-1併用の化学放射線療法を4例に行った。S-1は2週間投与1週間休薬で投与した。2例にX線照射,2例に陽子線照射が行われた。結果: 陽子線照射を行った2例の無増悪期間は31か月と36か月であった。一方,X線照射を行った2例の無増悪期間は24か月と21か月であった。考察: S-1は,dihydropyrimidine dehydrogenase(DPD)阻害による高い抗腫瘍効果が得られるだけでなく癌の放射線感受性を上昇させることが知られており,放射線照射に併用する抗癌剤としては理想的と考えられる。本報告の4例の局所制御が良好なことから,S-1併用の化学放射線療法は有用な集学的治療であると考えられる。
目次
Summary
Introduction: Although chemotherapy is the main treatment for recurrent colorectal cancer, the utility of radiotherapy as a local treatment has been widely reported. We performed chemoradiotherapy with S-1 for cases with recurrence after surgery, and the outcomes are reported herein. Materials and methods: Chemoradiotherapy with S-1 was performed in 4 cases. S-1 was administered for 2 weeks during the irradiation period, and the off period provided was 1 week. RESULTS: X-ray irradiation was performed in 2 cases and proton beam irradiation in the other 2. The progression free periods of the 2 cases receiving proton beam irradiation were 31 months and 36 months. In contrast, the progression free periods of the 2 cases given X-ray irradiation were 24 months and 21 months. Discussion: It is known that S-1 not only achieves a high anticancer effect via dihydropyrimidine dehydrogenase(DPD)inhibition, which is a major metabolic pathway of 5-FU, but also increases the radiation susceptibility of malignancies. S-1 is regarded as an ideal anticancer agent when used in combination with radiation therapy. Since the local control achieved in our 4 cases was good, chemoradiotherapy with S-1 was considered to be a useful treatment.
要旨
背景: 再発大腸癌に対する治療は化学療法が主体となるが,局所治療としての放射線治療の有用性も多く報告されている。大腸癌術後の再発症例に対して,S-1併用の化学放射線療法を施行したので治療成績を報告する。対象・方法: S-1併用の化学放射線療法を4例に行った。S-1は2週間投与1週間休薬で投与した。2例にX線照射,2例に陽子線照射が行われた。結果: 陽子線照射を行った2例の無増悪期間は31か月と36か月であった。一方,X線照射を行った2例の無増悪期間は24か月と21か月であった。考察: S-1は,dihydropyrimidine dehydrogenase(DPD)阻害による高い抗腫瘍効果が得られるだけでなく癌の放射線感受性を上昇させることが知られており,放射線照射に併用する抗癌剤としては理想的と考えられる。本報告の4例の局所制御が良好なことから,S-1併用の化学放射線療法は有用な集学的治療であると考えられる。