内容紹介
Status of Hepatic Lymph Node Involvement in Patients with Resectable Liver Metastasis of Colorectal Cancer after Preoperative Chemotherapy
Summary
The liver is the most common metastatic site for colorectal cancer(CRC). The 5-year survival rate of resected cases has been reported to be about 40%. Hepatic lymph node metastasis is reportedly associated with a poor prognosis in patients with liver metastases of CRC. The incidence of hepatic lymph node involvement in patients with liver metastases of CRC ranges from 5% to 28%. However, few reports have focused on hepatic lymph node involvement in patients with resectable liver metastasis who have undergone preoperative chemotherapy. This retrospective study was undertaken to address this issue. The subjects were 33 consecutive patients who had undergone the resection of liver metastases of CRC with hepatic lymph node sampling after preoperative chemotherapy between 2001 and 2016. Hepatic lymph node metastasis was confirmed in only one patient(3%). There was no significant difference in the frequency of hepatic lymph node metastasis between the cases with or without preoperative chemotherapy. The further collection of data is warranted to elucidate the significance of hepatic lymph node involvement in patients with liver metastases of CRC treated with preoperative chemotherapy.
要旨
大腸癌肝転移症例における肝所属リンパ節転移は5～28%に生じ,予後不良因子と報告されている。近年,新規抗悪性腫瘍薬の出現により術前化学療法の有用性が示されはじめている。しかし術前化学療法を施行した肝転移切除例における肝所属リンパ節転移を検討した報告は極めて少なく,その頻度や特徴を明らかにすることを目的に検討を行った。対象は2001～2016年までに当科で術前化学療法施行後肝切除を施行した大腸癌肝転移症例33例とした。肝切除時に肝所属リンパ節をサンプリングした。転移を認めたのは1例(3%)であった。当科における術前化学療法非施行80例と比較すると,術前化学療法施行例はH Stageの進行した症例が多かったが,肝所属リンパ節転移率には有意差は認めなかった。
目次
Summary
The liver is the most common metastatic site for colorectal cancer(CRC). The 5-year survival rate of resected cases has been reported to be about 40%. Hepatic lymph node metastasis is reportedly associated with a poor prognosis in patients with liver metastases of CRC. The incidence of hepatic lymph node involvement in patients with liver metastases of CRC ranges from 5% to 28%. However, few reports have focused on hepatic lymph node involvement in patients with resectable liver metastasis who have undergone preoperative chemotherapy. This retrospective study was undertaken to address this issue. The subjects were 33 consecutive patients who had undergone the resection of liver metastases of CRC with hepatic lymph node sampling after preoperative chemotherapy between 2001 and 2016. Hepatic lymph node metastasis was confirmed in only one patient(3%). There was no significant difference in the frequency of hepatic lymph node metastasis between the cases with or without preoperative chemotherapy. The further collection of data is warranted to elucidate the significance of hepatic lymph node involvement in patients with liver metastases of CRC treated with preoperative chemotherapy.
要旨
大腸癌肝転移症例における肝所属リンパ節転移は5～28%に生じ,予後不良因子と報告されている。近年,新規抗悪性腫瘍薬の出現により術前化学療法の有用性が示されはじめている。しかし術前化学療法を施行した肝転移切除例における肝所属リンパ節転移を検討した報告は極めて少なく,その頻度や特徴を明らかにすることを目的に検討を行った。対象は2001～2016年までに当科で術前化学療法施行後肝切除を施行した大腸癌肝転移症例33例とした。肝切除時に肝所属リンパ節をサンプリングした。転移を認めたのは1例(3%)であった。当科における術前化学療法非施行80例と比較すると,術前化学療法施行例はH Stageの進行した症例が多かったが,肝所属リンパ節転移率には有意差は認めなかった。