内容紹介
Summary
Intensive chemotherapy plus molecular targeted agent improve overall survival for patients with unresectable colorectal cancer. We performed laparoscopic surgery following intensive chemotherapy of mFOLFOX6 or FOLFIRI plus molecular targeted agent for 3 patients with unresectable locally advanced colorectal cancer with abscess formation. A 60-year-old man was diagnosed as having unresectable rectal cancer with abscess formation and underwent curative resection after partial response following chemotherapy. A 42-year-old woman was diagnosed as having unresectable sigmoid colon cancer with abscess formation and underwent curative resection after partial response following chemotherapy. A 56-year-old woman was diagnosed as having unresectable sigmoid colon cancer with abscess formation and underwent curative resection after partial response following chemotherapy. They are alive after surgery for 69, 74 and 72 months, respectively. Intensive chemotherapy plus molecular targeted agent for unresectalbe locally advanced colorectal cancer with abscess formation will be one of useful strategies for minimum invasive surgery and effective local control.
要旨
切除不能大腸癌に対する化学療法は,分子標的薬も加わり治療成績が向上している。われわれは膿瘍形成を伴う切除不能局所進行大腸癌に対し,mFOLFOX6やFOLFIRIに分子標的薬を加えた治療後に腹腔鏡下手術を行った3例を経験した。症例1は60歳,男性。膿瘍形成性直腸癌の診断で化学療法を行い,縮小効果が得られたため根治切除術を行った。症例2は42歳,女性。膿瘍形成性S状結腸癌の診断で化学療法を行い,縮小効果が得られたため根治切除術を行った。症例3は56歳,女性。膿瘍形成性S状結腸癌の診断で化学療法を行い,縮小効果が得られたため根治切除術を行った。それぞれ術後69,74,72か月経過し,現在生存中である。切除不能な膿瘍形成性大腸癌に対する分子標的薬併用化学療法は,手術侵襲の低減と局所制御が期待でき,有用な治療戦略の一つになると考えられた。
目次
Intensive chemotherapy plus molecular targeted agent improve overall survival for patients with unresectable colorectal cancer. We performed laparoscopic surgery following intensive chemotherapy of mFOLFOX6 or FOLFIRI plus molecular targeted agent for 3 patients with unresectable locally advanced colorectal cancer with abscess formation. A 60-year-old man was diagnosed as having unresectable rectal cancer with abscess formation and underwent curative resection after partial response following chemotherapy. A 42-year-old woman was diagnosed as having unresectable sigmoid colon cancer with abscess formation and underwent curative resection after partial response following chemotherapy. A 56-year-old woman was diagnosed as having unresectable sigmoid colon cancer with abscess formation and underwent curative resection after partial response following chemotherapy. They are alive after surgery for 69, 74 and 72 months, respectively. Intensive chemotherapy plus molecular targeted agent for unresectalbe locally advanced colorectal cancer with abscess formation will be one of useful strategies for minimum invasive surgery and effective local control.
要旨
切除不能大腸癌に対する化学療法は,分子標的薬も加わり治療成績が向上している。われわれは膿瘍形成を伴う切除不能局所進行大腸癌に対し,mFOLFOX6やFOLFIRIに分子標的薬を加えた治療後に腹腔鏡下手術を行った3例を経験した。症例1は60歳,男性。膿瘍形成性直腸癌の診断で化学療法を行い,縮小効果が得られたため根治切除術を行った。症例2は42歳,女性。膿瘍形成性S状結腸癌の診断で化学療法を行い,縮小効果が得られたため根治切除術を行った。症例3は56歳,女性。膿瘍形成性S状結腸癌の診断で化学療法を行い,縮小効果が得られたため根治切除術を行った。それぞれ術後69,74,72か月経過し,現在生存中である。切除不能な膿瘍形成性大腸癌に対する分子標的薬併用化学療法は,手術侵襲の低減と局所制御が期待でき,有用な治療戦略の一つになると考えられた。