内容紹介
Summary
We report a case of effective S-1 plus oxaliplatin (SOX) treatment for duodenal cancer with liver metastases. The patient was a 70-year-old female diagnosed with duodenal carcinoma that was unresectable because of liver metastasis(cT4N1M1, cStage Ⅳ in UICC 7th). She received SOX treatment(100 mg/m2 of oxaliplatin on day 1 combined with 40 mg/day of S-1 twice daily on days 1-14, was repeated every 3 weeks). After 4 courses, a partial response was confirmed by computed tomography and no severe adverse events were observed. However, during the 5th courses, several new liver metastases were observed, so we changed to weekly paclitaxel treatment. This case suggests that SOX treatment may be an effective chemotherapy for advanced primary duodenal carcinoma.
要旨
症例は70歳,女性。出血性十二指腸潰瘍の診断で近医より紹介された。上部消化管内視鏡検査を施行したところ,十二指腸球部に3型腫瘍を認め,生検にて腺癌が検出された。術前画像検査で肝臓S4に転移を認めたため,cT4N1M1,cStage Ⅳの診断で全身化学療法の方針とし,S-1+oxaliplatin(SOX療法)を行った。4コース終了後,腫瘍マーカーは著明に改善し,画像検査上でも37.5%の縮小を認めた。しかし5コース施行中に新規肝転移を認めたためPDと判断し,weekly paclitaxel療法に変更した。SOX療法は十二指腸癌に対する化学療法の一つとして有用である可能性が考えられた。
目次
We report a case of effective S-1 plus oxaliplatin (SOX) treatment for duodenal cancer with liver metastases. The patient was a 70-year-old female diagnosed with duodenal carcinoma that was unresectable because of liver metastasis(cT4N1M1, cStage Ⅳ in UICC 7th). She received SOX treatment(100 mg/m2 of oxaliplatin on day 1 combined with 40 mg/day of S-1 twice daily on days 1-14, was repeated every 3 weeks). After 4 courses, a partial response was confirmed by computed tomography and no severe adverse events were observed. However, during the 5th courses, several new liver metastases were observed, so we changed to weekly paclitaxel treatment. This case suggests that SOX treatment may be an effective chemotherapy for advanced primary duodenal carcinoma.
要旨
症例は70歳,女性。出血性十二指腸潰瘍の診断で近医より紹介された。上部消化管内視鏡検査を施行したところ,十二指腸球部に3型腫瘍を認め,生検にて腺癌が検出された。術前画像検査で肝臓S4に転移を認めたため,cT4N1M1,cStage Ⅳの診断で全身化学療法の方針とし,S-1+oxaliplatin(SOX療法)を行った。4コース終了後,腫瘍マーカーは著明に改善し,画像検査上でも37.5%の縮小を認めた。しかし5コース施行中に新規肝転移を認めたためPDと判断し,weekly paclitaxel療法に変更した。SOX療法は十二指腸癌に対する化学療法の一つとして有用である可能性が考えられた。