内容紹介
Summary
Tumor lysis syndrome(TLS)is a life-threatening metabolic complication caused by the rapid breakdown of malignant cells. It is an oncologic emergency and occurs spontaneously after the initiation of chemotherapy for hematological malignancies. Therefore, the management of TLS is important. Rasburicase(RSB)has been shown to be effective for the management of TLS. We retrospectively investigated the optimal administration period of RSB(1 to 7 days)for 38 adult patients with a hematological malignancy who were at high risk for TLS. In all patients, the serum uric acid(sUA)value did not increase beyond the upper limit of normal. Clinical TLS did not occur in any patients. Seven patients were administered a single-dose of RSB and sUA remained within normal limits. These results suggested that single-dose RSB administration was efficacious for Japanese adult patients with hematological malignancies who are at high risk for TLS.
目次
Tumor lysis syndrome(TLS)is a life-threatening metabolic complication caused by the rapid breakdown of malignant cells. It is an oncologic emergency and occurs spontaneously after the initiation of chemotherapy for hematological malignancies. Therefore, the management of TLS is important. Rasburicase(RSB)has been shown to be effective for the management of TLS. We retrospectively investigated the optimal administration period of RSB(1 to 7 days)for 38 adult patients with a hematological malignancy who were at high risk for TLS. In all patients, the serum uric acid(sUA)value did not increase beyond the upper limit of normal. Clinical TLS did not occur in any patients. Seven patients were administered a single-dose of RSB and sUA remained within normal limits. These results suggested that single-dose RSB administration was efficacious for Japanese adult patients with hematological malignancies who are at high risk for TLS.