内容紹介
Summary
We report a case of microangiopathic hemolytic anemia(MHA)caused by metastatic breast cancer treated with weekly paclitaxel. A 58-year-old woman was diagnosed with metastatic breast cancer 2 years earlier. She was treated with various chemotherapy regimens and hormonal therapy, before being switched to fulvestrant 3 months earlier. She presented with severe anemia, and was diagnosed with MHA with bone marrow carcinomatosis following bone marrow biopsy. She was treated with weekly paclitaxel and recovered successfully. A subsequent biopsy showed that the bone marrow carcinomatosis had decreased. MHA due to breast cancer is rare and is associated with poor prognosis; however, rapid initiation of chemotherapy may be effective.
要旨
症例は58歳,女性。転移性乳癌にて2年前より加療中である。めまい,ふらつきと高度貧血を認め,骨髄生検により骨髄癌症に合併する細小血管障害性溶血性貧血(microangiopathic hemolytic anemia: MHA)と診断した。weekly paclitaxel療法を導入したところ,溶血性貧血は速やかに改善,再生検にて効果を確認した。MHAは骨髄癌症により起こる病態で非常に予後不良であるが,早期治療が奏効する可能性がある。
目次
We report a case of microangiopathic hemolytic anemia(MHA)caused by metastatic breast cancer treated with weekly paclitaxel. A 58-year-old woman was diagnosed with metastatic breast cancer 2 years earlier. She was treated with various chemotherapy regimens and hormonal therapy, before being switched to fulvestrant 3 months earlier. She presented with severe anemia, and was diagnosed with MHA with bone marrow carcinomatosis following bone marrow biopsy. She was treated with weekly paclitaxel and recovered successfully. A subsequent biopsy showed that the bone marrow carcinomatosis had decreased. MHA due to breast cancer is rare and is associated with poor prognosis; however, rapid initiation of chemotherapy may be effective.
要旨
症例は58歳,女性。転移性乳癌にて2年前より加療中である。めまい,ふらつきと高度貧血を認め,骨髄生検により骨髄癌症に合併する細小血管障害性溶血性貧血(microangiopathic hemolytic anemia: MHA)と診断した。weekly paclitaxel療法を導入したところ,溶血性貧血は速やかに改善,再生検にて効果を確認した。MHAは骨髄癌症により起こる病態で非常に予後不良であるが,早期治療が奏効する可能性がある。