内容紹介
Summary
The subject was a 63-year-old man. The patient was transported by ambulance to the hospital because of dyspnea caused by carcinomatous pleurisy and carcinomatous pericarditis, after which pericardial drainage was performed; however, Staphylococcus aureus bacteremia arose as a complication. Adequate control of carcinomatous serositis was achieved using chemotherapy, including albumin-bound paclitaxel(nab-PTX), which is a nanoparticle formulation binding human serum albumin and paclitaxel, in combination with 1 course of antibiotics. For cancerous serositis cases, platinum combination chemotherapy using nab-PTX is believed to be 1 treatment option in which good disease control can be expected along with bevacizumab, whose efficacy has already been confirmed.
要旨
症例は63歳,男性。癌性胸膜炎と癌性心膜炎による呼吸困難で救急搬送され,心囊ドレナージを施行されるも黄色ブドウ球菌性菌血症を併発した。抗生剤治療を併用し,ヒト血清アルブミンとパクリタキセルを結合させたナノ粒子製剤であるアルブミン懸濁型パクリタキセル(nab-PTX)を含む化学療法にて良好な癌性漿膜炎の制御を得た。癌性漿膜炎症例に対しては,すでに有効性の確認されているbevacizumabとともにnab-PTXを使用するプラチナ併用化学療法は病勢制御を期待し得る治療選択肢の一つと考えられる。
目次
The subject was a 63-year-old man. The patient was transported by ambulance to the hospital because of dyspnea caused by carcinomatous pleurisy and carcinomatous pericarditis, after which pericardial drainage was performed; however, Staphylococcus aureus bacteremia arose as a complication. Adequate control of carcinomatous serositis was achieved using chemotherapy, including albumin-bound paclitaxel(nab-PTX), which is a nanoparticle formulation binding human serum albumin and paclitaxel, in combination with 1 course of antibiotics. For cancerous serositis cases, platinum combination chemotherapy using nab-PTX is believed to be 1 treatment option in which good disease control can be expected along with bevacizumab, whose efficacy has already been confirmed.
要旨
症例は63歳,男性。癌性胸膜炎と癌性心膜炎による呼吸困難で救急搬送され,心囊ドレナージを施行されるも黄色ブドウ球菌性菌血症を併発した。抗生剤治療を併用し,ヒト血清アルブミンとパクリタキセルを結合させたナノ粒子製剤であるアルブミン懸濁型パクリタキセル(nab-PTX)を含む化学療法にて良好な癌性漿膜炎の制御を得た。癌性漿膜炎症例に対しては,すでに有効性の確認されているbevacizumabとともにnab-PTXを使用するプラチナ併用化学療法は病勢制御を期待し得る治療選択肢の一つと考えられる。