内容紹介
Summary
The patient was a 50-year-old man. Abdominal ultrasound performed as part of a regular check-up suggested the presence of a tumor in the left kidney, and he was referred to our hospital for further examination. Computed tomography(CT)and magnetic resonance imaging(MRI)revealed the presence of a cystic neoplasm of the pancreas with partial calcification. The tumor had a maximum diameter of approximately 12 cm. Based on these findings, the patient was diagnosed with solid pseudopapillary neoplasm(SPN)and underwent distal pancreatectomy and splenectomy. Pathological findings indicated that a large proportion of the tumor was composed of cells with clear cytoplasm and small, oval nuclei, while some parts of the tumor were composed of atypical cells. Immunohistochemistry further demonstrated that the tumor expressed vimentin, nuclear β-catenin, and CD10. These findings confirmed the diagnosis of SPN. Atypical cells in the tumor were p53-positive, and some were exposed with damaged membranes. The patient has been followed up due to the possibility of tumor recurrence. The tumor has not recurred for approximately 32 months since surgery. Previous studies demonstrated that SPN is more common in women. We report the case of SPN in a male patient and discuss the literature.
要旨
症例は50歳,男性。健康診断の腹部超音波検査にて左腎腫瘍疑いの診断を受け,精査目的にて当院を受診した。CT,MRI検査では最大径約12 cmの膵由来の多囊胞腫瘍で一部石灰化を伴う所見からsolid pseudopapillary neoplasm(SPN)と診断し,脾臓合併膵体尾部切除術を施行した。病理組織診断では淡明な細胞質と小型の類円形核からなる細胞腫瘍が多くを占め,一部やや異型な細胞からなる箇所を認めた。免疫組織学的にvimentin(+),β-catenin(核+),CD10(+)からSPNと診断された。被膜が欠損して露出する箇所があり,再発を念頭に置いて経過観察している。切除から約32か月再発を認めていない。SPNは女性に多いと報告されていたが,男性症例を経験したので文献的考察を加えて報告する。
目次
The patient was a 50-year-old man. Abdominal ultrasound performed as part of a regular check-up suggested the presence of a tumor in the left kidney, and he was referred to our hospital for further examination. Computed tomography(CT)and magnetic resonance imaging(MRI)revealed the presence of a cystic neoplasm of the pancreas with partial calcification. The tumor had a maximum diameter of approximately 12 cm. Based on these findings, the patient was diagnosed with solid pseudopapillary neoplasm(SPN)and underwent distal pancreatectomy and splenectomy. Pathological findings indicated that a large proportion of the tumor was composed of cells with clear cytoplasm and small, oval nuclei, while some parts of the tumor were composed of atypical cells. Immunohistochemistry further demonstrated that the tumor expressed vimentin, nuclear β-catenin, and CD10. These findings confirmed the diagnosis of SPN. Atypical cells in the tumor were p53-positive, and some were exposed with damaged membranes. The patient has been followed up due to the possibility of tumor recurrence. The tumor has not recurred for approximately 32 months since surgery. Previous studies demonstrated that SPN is more common in women. We report the case of SPN in a male patient and discuss the literature.
要旨
症例は50歳,男性。健康診断の腹部超音波検査にて左腎腫瘍疑いの診断を受け,精査目的にて当院を受診した。CT,MRI検査では最大径約12 cmの膵由来の多囊胞腫瘍で一部石灰化を伴う所見からsolid pseudopapillary neoplasm(SPN)と診断し,脾臓合併膵体尾部切除術を施行した。病理組織診断では淡明な細胞質と小型の類円形核からなる細胞腫瘍が多くを占め,一部やや異型な細胞からなる箇所を認めた。免疫組織学的にvimentin(+),β-catenin(核+),CD10(+)からSPNと診断された。被膜が欠損して露出する箇所があり,再発を念頭に置いて経過観察している。切除から約32か月再発を認めていない。SPNは女性に多いと報告されていたが,男性症例を経験したので文献的考察を加えて報告する。