内容紹介
Summary
Recently, bisphosphonate and denosumab have been widely used for the treatment of bone metastasis of breast cancer. However, medication-related osteonecrosis of the jaw(MRONJ)has often been reported as a side effect of these drugs. We experienced a rare case of intracranial epidural abscess secondary to MRONJ. The patient died of the condition, although chemotherapy was effective. The mechanism of and therapy for MRONJ have not been clarified; therefore, its prevention should be emphasized.
要旨
乳癌骨転移の患者に化学療法に加えbisphosphonateとdenosumabを投与した。化学療法は有効であったが,顎骨壊死が発症しこれが頭蓋内硬膜外膿瘍にまでおよび死亡した。これらの薬剤の薬剤関連顎骨壊死の報告が散見されるが,頭蓋内硬膜外膿瘍まで来した症例はまれである。顎骨壊死の機序や治療の詳細は不明であり,投与時には予防手段としての口腔ケアの重要性が示唆された。
目次
Recently, bisphosphonate and denosumab have been widely used for the treatment of bone metastasis of breast cancer. However, medication-related osteonecrosis of the jaw(MRONJ)has often been reported as a side effect of these drugs. We experienced a rare case of intracranial epidural abscess secondary to MRONJ. The patient died of the condition, although chemotherapy was effective. The mechanism of and therapy for MRONJ have not been clarified; therefore, its prevention should be emphasized.
要旨
乳癌骨転移の患者に化学療法に加えbisphosphonateとdenosumabを投与した。化学療法は有効であったが,顎骨壊死が発症しこれが頭蓋内硬膜外膿瘍にまでおよび死亡した。これらの薬剤の薬剤関連顎骨壊死の報告が散見されるが,頭蓋内硬膜外膿瘍まで来した症例はまれである。顎骨壊死の機序や治療の詳細は不明であり,投与時には予防手段としての口腔ケアの重要性が示唆された。