内容紹介
Summary
Hiccups are occasionally experienced by most individuals, and although not life-threatening, they may lead to a decline in quality of life. Shitei extract(shitei, persimmon calyx)may be used for the treatment of hiccups. The effects of shitei extract were investigated in patients admitted to the Japanese Red Cross Musashino Hospital between October 2011 and May 2016. Numerous prescriptions for shitei extract were reported in the Department of Respiratory Organs and Neurosurgery. The primary causes of hiccups were chemotherapy and brain disease. Of 149 patients, 107(71.8%)suffered from hiccups. None of the patients reported adverse events related to the administration of shitei extract. The incidence of hiccups was significantly higher in patients with brain disease(p=0.0075), treated with chemotherapy for cancer(p=0.0402), or requiring the insertion of a gastric tube(p=0.0065). Among those treated with chemotherapy for cancer, shitei extract was effective against hiccups in 82.0% patients(45 of 55). Furthermore, four patients received prophylaxis with shitei extract for the prevention of hiccups after chemotherapy. In conclusion, these results indicate that shitei extract is an effective and safe therapeutic drug for the treatment of hiccups. In particular, shitei extract was effective in the prevention of hiccups after chemotherapy.
要旨
吃逆は患者QOLを低下させる要因となる。柿のヘタを煎じた製剤(柿のヘタ煎)は吃逆治療の選択肢の一つであるが,その有効性は十分に検証されていない。そこで,本製剤の処方実態と吃逆に対する有効性について調査した。2011年10月～2016年5月31日までの4年8か月間に柿のヘタ煎が処方された患者を対象に後ろ向き調査を実施した。吃逆の主因として化学療法および脳疾患関連が認められた。吃逆に対し柿のヘタ煎が投与された149名のうち107名(71.8%)で有効性を認めた。効果は脳病変(p=0.0075),化学療法(p=0.0402),胃管の挿入(p=0.0065)によって有意に向上した。特に,本製剤は化学療法後の吃逆患者55名中45名(82.0%)において有効であった。本研究より,柿のヘタ煎は化学療法関連吃逆に対して高い有効率を示すとともに,予防投与に有用である可能性が示唆された。
目次
Hiccups are occasionally experienced by most individuals, and although not life-threatening, they may lead to a decline in quality of life. Shitei extract(shitei, persimmon calyx)may be used for the treatment of hiccups. The effects of shitei extract were investigated in patients admitted to the Japanese Red Cross Musashino Hospital between October 2011 and May 2016. Numerous prescriptions for shitei extract were reported in the Department of Respiratory Organs and Neurosurgery. The primary causes of hiccups were chemotherapy and brain disease. Of 149 patients, 107(71.8%)suffered from hiccups. None of the patients reported adverse events related to the administration of shitei extract. The incidence of hiccups was significantly higher in patients with brain disease(p=0.0075), treated with chemotherapy for cancer(p=0.0402), or requiring the insertion of a gastric tube(p=0.0065). Among those treated with chemotherapy for cancer, shitei extract was effective against hiccups in 82.0% patients(45 of 55). Furthermore, four patients received prophylaxis with shitei extract for the prevention of hiccups after chemotherapy. In conclusion, these results indicate that shitei extract is an effective and safe therapeutic drug for the treatment of hiccups. In particular, shitei extract was effective in the prevention of hiccups after chemotherapy.
要旨
吃逆は患者QOLを低下させる要因となる。柿のヘタを煎じた製剤(柿のヘタ煎)は吃逆治療の選択肢の一つであるが,その有効性は十分に検証されていない。そこで,本製剤の処方実態と吃逆に対する有効性について調査した。2011年10月～2016年5月31日までの4年8か月間に柿のヘタ煎が処方された患者を対象に後ろ向き調査を実施した。吃逆の主因として化学療法および脳疾患関連が認められた。吃逆に対し柿のヘタ煎が投与された149名のうち107名(71.8%)で有効性を認めた。効果は脳病変(p=0.0075),化学療法(p=0.0402),胃管の挿入(p=0.0065)によって有意に向上した。特に,本製剤は化学療法後の吃逆患者55名中45名(82.0%)において有効であった。本研究より,柿のヘタ煎は化学療法関連吃逆に対して高い有効率を示すとともに,予防投与に有用である可能性が示唆された。