内容紹介
Summary
An 84-year-old woman had locally advanced sigmoid colon cancer that was unresectable because of deep invasion in the left pelvic wall. Transverse double-barrel colostomy was performed owing to stenosis in the sigmoid colon. The patient's performance status score was 2, and it was difficult to administer cytotoxic chemotherapy. Single-agent panitumumab chemotherapy was initiated. In addition, although S-1 was administered for 4 days in the fourth cycle, it was discontinued owing to drug intolerance. Panitumumab was administered seven times. The tumor size markedly reduced, and sigmoid colectomy was performed. Thus, single-agent panitumumab chemotherapy is a possible treatment option for advanced colorectal cancer in elderly patients.
要旨
症例は84歳,女性。骨盤壁への広範囲浸潤を伴い,一期的根治切除が困難な局所進行S状結腸癌を認めた。狭窄を認めたため,横行結腸双孔式人工肛門造設術を行った。performance status 2の高齢者で,殺細胞性抗癌剤は投与が難しいと判断し,panitumumab(Pmab)単剤投与による化学療法を開始した。4コース目にS-1を4日間内服したが,忍容性がなく中止した。計7コース施行し,腫瘍が著明に縮小したためS状結腸切除術を行った。高齢者に対する化学療法は忍容性が問題となる。Pmab単剤投与は高齢者進行大腸癌の有効な治療選択肢になり得ると考えた。
目次
An 84-year-old woman had locally advanced sigmoid colon cancer that was unresectable because of deep invasion in the left pelvic wall. Transverse double-barrel colostomy was performed owing to stenosis in the sigmoid colon. The patient's performance status score was 2, and it was difficult to administer cytotoxic chemotherapy. Single-agent panitumumab chemotherapy was initiated. In addition, although S-1 was administered for 4 days in the fourth cycle, it was discontinued owing to drug intolerance. Panitumumab was administered seven times. The tumor size markedly reduced, and sigmoid colectomy was performed. Thus, single-agent panitumumab chemotherapy is a possible treatment option for advanced colorectal cancer in elderly patients.
要旨
症例は84歳,女性。骨盤壁への広範囲浸潤を伴い,一期的根治切除が困難な局所進行S状結腸癌を認めた。狭窄を認めたため,横行結腸双孔式人工肛門造設術を行った。performance status 2の高齢者で,殺細胞性抗癌剤は投与が難しいと判断し,panitumumab(Pmab)単剤投与による化学療法を開始した。4コース目にS-1を4日間内服したが,忍容性がなく中止した。計7コース施行し,腫瘍が著明に縮小したためS状結腸切除術を行った。高齢者に対する化学療法は忍容性が問題となる。Pmab単剤投与は高齢者進行大腸癌の有効な治療選択肢になり得ると考えた。