内容紹介
Summary
The patient was a 65-year-old man who developed dyspnea after 6 courses of S-1 and oxaliplatin(SOX)chemotherapy for advanced stomach cancer. The chemotherapy regimen consisted of SOX chemotherapy. The patient developed hypoxemia, and chest radiography revealed ground-glass opacity in both lungs. Bronchoscopy and DLST led to a diagnosis of drug-induced lung injury caused by S-1. Although steroid pulse therapy was administered, the patient's condition deteriorated rapidly and was ultimately fatal. Based on the clinical course and histopathological findings, a DAD-type lung disorder was diagnosed. This description of a DAD-type drug-induced lung injury caused by S-1, for which histopathological findings were available in the early stages, is clinically valuable. We report this case along with a review of the relevant literature.
要旨
症例は65歳,男性。進行胃癌に対しS-1+oxaliplatin(SOX)療法を6コース施行後に呼吸困難が出現し,低酸素血症と胸部CTで両側上葉優位にすりガラス陰影を認めた。気管支鏡検査,DLSTを施行しS-1による薬剤性肺障害と診断した。ステロイドパルス療法を行うも急速に呼吸状態が悪化し死亡した。臨床経過と病理組織学的所見よりDAD型肺障害と診断した。本例は発症早期の病理所見が得られたS-1によるDAD型薬剤性肺障害の貴重な症例であり,文献的考察を含め報告する。
目次
The patient was a 65-year-old man who developed dyspnea after 6 courses of S-1 and oxaliplatin(SOX)chemotherapy for advanced stomach cancer. The chemotherapy regimen consisted of SOX chemotherapy. The patient developed hypoxemia, and chest radiography revealed ground-glass opacity in both lungs. Bronchoscopy and DLST led to a diagnosis of drug-induced lung injury caused by S-1. Although steroid pulse therapy was administered, the patient's condition deteriorated rapidly and was ultimately fatal. Based on the clinical course and histopathological findings, a DAD-type lung disorder was diagnosed. This description of a DAD-type drug-induced lung injury caused by S-1, for which histopathological findings were available in the early stages, is clinically valuable. We report this case along with a review of the relevant literature.
要旨
症例は65歳,男性。進行胃癌に対しS-1+oxaliplatin(SOX)療法を6コース施行後に呼吸困難が出現し,低酸素血症と胸部CTで両側上葉優位にすりガラス陰影を認めた。気管支鏡検査,DLSTを施行しS-1による薬剤性肺障害と診断した。ステロイドパルス療法を行うも急速に呼吸状態が悪化し死亡した。臨床経過と病理組織学的所見よりDAD型肺障害と診断した。本例は発症早期の病理所見が得られたS-1によるDAD型薬剤性肺障害の貴重な症例であり,文献的考察を含め報告する。