内容紹介
Summary
After undergoing an upper gastrointestinal endoscopy, a 74-year-old woman with anemia was diagnosed with advanced lower gastric cancer. We performed laparotomy and identified the tumor as unresectable because of the direct invasion to the pancreas. S-1 was administered at 60 mg/day for 2 weeks followed by 1-week discontinuation. After 6 weeks, we changed the schedule to the same dosage of S-1 for 1 week followed by 2-week discontinuation. CT and endoscopic findings showed complete response after 64 weeks of S-1 administration. Since then, S-1 has been maintained at 60 mg/day intermittently for 14 days in 7 weeks according to the patient's condition. The patient is currently doing well with a complete response for more than 5 years.
要旨
症例は74歳,女性。貧血精査目的の上部消化管内視鏡検査で胃癌と診断された。開腹手術を施行するも膵浸潤を認めたため,切除不能と判断し胃空腸吻合術のみ施行した。S-1(60 mg/day)を2週投与1週休薬で開始した後,1週投与2週休薬に変更して治療を継続した。投与開始64週後にcomplete response(CR)となり,それ以降は7週間で14日分のS-1を60mg/dayで体調に合わせて可能な時に内服しながら5年以上CRを継続している。
目次
After undergoing an upper gastrointestinal endoscopy, a 74-year-old woman with anemia was diagnosed with advanced lower gastric cancer. We performed laparotomy and identified the tumor as unresectable because of the direct invasion to the pancreas. S-1 was administered at 60 mg/day for 2 weeks followed by 1-week discontinuation. After 6 weeks, we changed the schedule to the same dosage of S-1 for 1 week followed by 2-week discontinuation. CT and endoscopic findings showed complete response after 64 weeks of S-1 administration. Since then, S-1 has been maintained at 60 mg/day intermittently for 14 days in 7 weeks according to the patient's condition. The patient is currently doing well with a complete response for more than 5 years.
要旨
症例は74歳,女性。貧血精査目的の上部消化管内視鏡検査で胃癌と診断された。開腹手術を施行するも膵浸潤を認めたため,切除不能と判断し胃空腸吻合術のみ施行した。S-1(60 mg/day)を2週投与1週休薬で開始した後,1週投与2週休薬に変更して治療を継続した。投与開始64週後にcomplete response(CR)となり,それ以降は7週間で14日分のS-1を60mg/dayで体調に合わせて可能な時に内服しながら5年以上CRを継続している。