内容紹介
Summary
To clarify the prognostic impact of postoperative inflammatory status, serum CRP levels on POD3 after radical resection(POD3 CRP)were evaluated as an indicator of inflammatory response after surgery in patients with colorectal cancer. Of the colorectal cancer patients who underwent radical resection at our department between 2000 and 2015, 916 patients with StageⅠ to Ⅳ disease were included in the analyses. The patients were divided into 2 groups according to high and low POD3 CRP levels. The POD3 CRP levels of the patients were analyzed for the 75th percentile that was 12.16 mg/dL(range, 0.06-33.78). The cancer-specific 5-year survival rate was 80.6% in patients in the high group and 90.5% in those in the low group, indicating poor prognosis in patients with high values. POD3 CRP levels were an independent prognostic factor in the multivariate analysis. It was suggested that the degree of inflammation after surgery influences the postoperative prognosis after radical resection for colorectal cancer.
要旨
大腸癌術後の炎症反応の指標として,治癒切除後第3病日の血清CRP値(POD3 CRP)について検討し,術後の炎症状態が予後に及ぼす影響を明らかにすることを目的とした。2000～2015年までに当科で治癒切除した大腸癌症例のうちStageⅠ～Ⅳ症例の916例を対象とした。対象例のPOD3 CRPは75%ile値12.16(0.06～33.78)mg/dLで,これを基に高値例と低値例の2群に分けて予後を検討した。結果,癌特異的5年生存率は高値例80.6%,低値例90.5%で高値例の予後が有意に不良であった。また,POD3 CRPは多変量解析でも独立した予後因子であった。大腸癌治癒切除後の炎症状態の程度が大腸癌治癒切除後の予後に影響を及ぼす可能性が示唆された。
目次
To clarify the prognostic impact of postoperative inflammatory status, serum CRP levels on POD3 after radical resection(POD3 CRP)were evaluated as an indicator of inflammatory response after surgery in patients with colorectal cancer. Of the colorectal cancer patients who underwent radical resection at our department between 2000 and 2015, 916 patients with StageⅠ to Ⅳ disease were included in the analyses. The patients were divided into 2 groups according to high and low POD3 CRP levels. The POD3 CRP levels of the patients were analyzed for the 75th percentile that was 12.16 mg/dL(range, 0.06-33.78). The cancer-specific 5-year survival rate was 80.6% in patients in the high group and 90.5% in those in the low group, indicating poor prognosis in patients with high values. POD3 CRP levels were an independent prognostic factor in the multivariate analysis. It was suggested that the degree of inflammation after surgery influences the postoperative prognosis after radical resection for colorectal cancer.
要旨
大腸癌術後の炎症反応の指標として,治癒切除後第3病日の血清CRP値(POD3 CRP)について検討し,術後の炎症状態が予後に及ぼす影響を明らかにすることを目的とした。2000～2015年までに当科で治癒切除した大腸癌症例のうちStageⅠ～Ⅳ症例の916例を対象とした。対象例のPOD3 CRPは75%ile値12.16(0.06～33.78)mg/dLで,これを基に高値例と低値例の2群に分けて予後を検討した。結果,癌特異的5年生存率は高値例80.6%,低値例90.5%で高値例の予後が有意に不良であった。また,POD3 CRPは多変量解析でも独立した予後因子であった。大腸癌治癒切除後の炎症状態の程度が大腸癌治癒切除後の予後に影響を及ぼす可能性が示唆された。