内容紹介
Summary
Background: Cisplatin(CDDP)-induced nephrotoxicity(CIN)is a critical complication of chemotherapy. Among patients undergoing chemotherapy with CDDP, short-hydration, and magnesium supplementation for lung cancer, this study was conducted to evaluate the frequency of CIN and utility of the predictive score. Methods: Patients who underwent chemotherapy with CDDP for lung cancer were retrospectively investigated. A multiple logistic regression analysis to detect the risk factors for CIN and receiver operating characteristic analysis to examine the discrimination of the predictive score were performed. Results: A total of 111 patients were included, with a total count of chemotherapy courses of 402 and a median count of chemotherapy courses of 4. CIN occurred in 9.9% of the patients, with grade 2 and higher in 7.2% and 87% of the CIN cases detected in the initial course, respectively. The significantly independent risk factors for CIN included the number of chemotherapy courses, female gender, and predictive score. The discriminative power of the predictive score was moderate. Conclusion: The predictive score for CIN was simple and useful in patients undergoing chemotherapy for lung cancer with CDDP, short-hydration, and magnesium supplementation, even in late courses.
要旨
目的: cisplatin(CDDP)誘発性腎障害(cisplatin-induced nephrotoxicity: CIN)は重大な化学療法の合併症になり得る。short-hydrationとマグネシウム補充を採用した肺癌化学療法患者群においてCINの合併状況を調べ,CINの予測スコアの有用性を検討した。方法: CDDPを含む化学療法を実施した肺癌患者を後方視的に検討した。CINの危険因子の抽出には多変量logistic回帰分析,予測スコアの判別力はreceiver operating characteristic解析を用いて検定した。結果: 患者数111人で総投与回数402回,投与回数中央値は4回であった。CIN 9.9%,grade 2以上は7.2%で合併し,87%は1回目投与であった。CINの独立した有意な危険因子は,CDDPの投与回数,女性,予測スコアであった。予測スコアのCIN合併の判別力は中等度であった。結論: 簡便なCIN合併の予測スコアはshort-hydrationとマグネシウム補充を採用した肺癌化学療法患者群の初回以降の投与においても有用であった。
目次
Background: Cisplatin(CDDP)-induced nephrotoxicity(CIN)is a critical complication of chemotherapy. Among patients undergoing chemotherapy with CDDP, short-hydration, and magnesium supplementation for lung cancer, this study was conducted to evaluate the frequency of CIN and utility of the predictive score. Methods: Patients who underwent chemotherapy with CDDP for lung cancer were retrospectively investigated. A multiple logistic regression analysis to detect the risk factors for CIN and receiver operating characteristic analysis to examine the discrimination of the predictive score were performed. Results: A total of 111 patients were included, with a total count of chemotherapy courses of 402 and a median count of chemotherapy courses of 4. CIN occurred in 9.9% of the patients, with grade 2 and higher in 7.2% and 87% of the CIN cases detected in the initial course, respectively. The significantly independent risk factors for CIN included the number of chemotherapy courses, female gender, and predictive score. The discriminative power of the predictive score was moderate. Conclusion: The predictive score for CIN was simple and useful in patients undergoing chemotherapy for lung cancer with CDDP, short-hydration, and magnesium supplementation, even in late courses.
要旨
目的: cisplatin(CDDP)誘発性腎障害(cisplatin-induced nephrotoxicity: CIN)は重大な化学療法の合併症になり得る。short-hydrationとマグネシウム補充を採用した肺癌化学療法患者群においてCINの合併状況を調べ,CINの予測スコアの有用性を検討した。方法: CDDPを含む化学療法を実施した肺癌患者を後方視的に検討した。CINの危険因子の抽出には多変量logistic回帰分析,予測スコアの判別力はreceiver operating characteristic解析を用いて検定した。結果: 患者数111人で総投与回数402回,投与回数中央値は4回であった。CIN 9.9%,grade 2以上は7.2%で合併し,87%は1回目投与であった。CINの独立した有意な危険因子は,CDDPの投与回数,女性,予測スコアであった。予測スコアのCIN合併の判別力は中等度であった。結論: 簡便なCIN合併の予測スコアはshort-hydrationとマグネシウム補充を採用した肺癌化学療法患者群の初回以降の投与においても有用であった。