内容紹介
Summary
A 67-year-old woman with a mass in the right breast was admitted to our hospital. The tumor measured 35 mm in diameter in the right breast, and the lymph node measured 30 mm in diameter in the right axilla. The mass was diagnosed as malignant based on core needle biopsy. Immunohistochemistry staining for synaptophysin, chromogranin A, and CD56 was positive, suggesting that the tumor was small cell carcinoma. Positron emission tomography-computed tomography imaging excluded any other primary disease. Thus, the patient was diagnosed as having primary small cell carcinoma of the breast. Modified radical mastectomy with axillary lymph node dissection was performed. The pathological diagnosis of the surgical material confirmed small cell carcinoma. The expression of estrogen, progesterone, and human epidermal growth factor receptors was negative. After surgery, chemotherapy- and radiotherapy-based breast cancer treatment were performed. The patient was relapse free 9 months after surgery.
要旨
われわれが経験した乳腺原発小細胞癌の1例を報告する。症例は67歳,女性。右乳房腫瘤を自覚し,近医より精査加療目的に当院紹介受診となった。右乳房ACE領域に35 mm大の境界明瞭な腫瘤と,右腋窩に30 mm大の腫大リンパ節を触知した。針生検の結果,synaptophysin陽性,chromogranin A陽性,CD56陽性の腫瘍細胞で小細胞癌と診断された。PET-CT検査では他に原発巣となる病変は認めず,乳腺原発小細胞癌として右乳房切除術+腋窩リンパ節郭清を施行した。最終病理組織学的結果は乳腺原発小細胞癌であり,ER,PgR,HER2とも陰性であった。乳癌に準じた術後補助化学療法と放射線治療を行い,術後9か月経過しているが無再発である。
目次
A 67-year-old woman with a mass in the right breast was admitted to our hospital. The tumor measured 35 mm in diameter in the right breast, and the lymph node measured 30 mm in diameter in the right axilla. The mass was diagnosed as malignant based on core needle biopsy. Immunohistochemistry staining for synaptophysin, chromogranin A, and CD56 was positive, suggesting that the tumor was small cell carcinoma. Positron emission tomography-computed tomography imaging excluded any other primary disease. Thus, the patient was diagnosed as having primary small cell carcinoma of the breast. Modified radical mastectomy with axillary lymph node dissection was performed. The pathological diagnosis of the surgical material confirmed small cell carcinoma. The expression of estrogen, progesterone, and human epidermal growth factor receptors was negative. After surgery, chemotherapy- and radiotherapy-based breast cancer treatment were performed. The patient was relapse free 9 months after surgery.
要旨
われわれが経験した乳腺原発小細胞癌の1例を報告する。症例は67歳,女性。右乳房腫瘤を自覚し,近医より精査加療目的に当院紹介受診となった。右乳房ACE領域に35 mm大の境界明瞭な腫瘤と,右腋窩に30 mm大の腫大リンパ節を触知した。針生検の結果,synaptophysin陽性,chromogranin A陽性,CD56陽性の腫瘍細胞で小細胞癌と診断された。PET-CT検査では他に原発巣となる病変は認めず,乳腺原発小細胞癌として右乳房切除術+腋窩リンパ節郭清を施行した。最終病理組織学的結果は乳腺原発小細胞癌であり,ER,PgR,HER2とも陰性であった。乳癌に準じた術後補助化学療法と放射線治療を行い,術後9か月経過しているが無再発である。