内容紹介
Summary
To determine factors related to the effectiveness of red blood cell transfusions in terminally ill cancer patients, we conducted a retrospective cohort study. We studied 27 terminally ill cancer patients who were transfused with red blood cells at our hospital between June 2015 and September 2017. Patients who responded to the treatment(“responders”; 16 cases[59%])were compared with those who did not(“non-responders”; 11 cases[40%]). Comparative predictive factor analysis revealed statistically significant differences between responders and non-responders in Eastern Cooperative Oncology Group performance status(PS)(p=0.004)and palliative prognostic index(PPI)scores(p=0.022). Furthermore, a statistically significant difference in median post-transfusion survival times(MST)(p=0.047)was found between responders(69 days; quartile range: 20-141 days)and non-responders(22 days; quartile range: 11-47 days). These results suggested that PPI and PS were significant predictors of the effectiveness of red blood cell transfusions in palliative care, and transfusion effectiveness was related to post-transfusion survival time.
要旨
終末期癌患者における赤血球輸血の効果と関連のある因子を明らかにすることを目的とした。対象は2015年6月～2017年9月までに当院緩和医療科で赤血球輸血した終末期癌患者27症例で,後ろ向きコホート研究を行った。輸血の効果があった患者群(以下,responders)16症例(59%)と効果がなかった患者群(以下,non-responders)11症例(40%)を比較した。赤血球輸血の効果予測因子解析では,Eastern Cooperative Oncology Group performance status(PS)(p=0.004),palliative prognostic index(PPI)(p=0.022)で統計学的に有意な差を認めた。生存時間分析では,respondersの生存期間中央値69(四分位範囲: 20～141)日とnon-respondersの生存期間中央値22(四分位範囲: 11～47)日で,生存期間に統計学的に有意な差(p=0.047)を認めた。PPI,PSは緩和ケアにおける赤血球輸血の効果予測因子として関連が示唆された。また,輸血効果と輸血後の生存期間に関連が示唆された。
目次
To determine factors related to the effectiveness of red blood cell transfusions in terminally ill cancer patients, we conducted a retrospective cohort study. We studied 27 terminally ill cancer patients who were transfused with red blood cells at our hospital between June 2015 and September 2017. Patients who responded to the treatment(“responders”; 16 cases[59%])were compared with those who did not(“non-responders”; 11 cases[40%]). Comparative predictive factor analysis revealed statistically significant differences between responders and non-responders in Eastern Cooperative Oncology Group performance status(PS)(p=0.004)and palliative prognostic index(PPI)scores(p=0.022). Furthermore, a statistically significant difference in median post-transfusion survival times(MST)(p=0.047)was found between responders(69 days; quartile range: 20-141 days)and non-responders(22 days; quartile range: 11-47 days). These results suggested that PPI and PS were significant predictors of the effectiveness of red blood cell transfusions in palliative care, and transfusion effectiveness was related to post-transfusion survival time.
要旨
終末期癌患者における赤血球輸血の効果と関連のある因子を明らかにすることを目的とした。対象は2015年6月～2017年9月までに当院緩和医療科で赤血球輸血した終末期癌患者27症例で,後ろ向きコホート研究を行った。輸血の効果があった患者群(以下,responders)16症例(59%)と効果がなかった患者群(以下,non-responders)11症例(40%)を比較した。赤血球輸血の効果予測因子解析では,Eastern Cooperative Oncology Group performance status(PS)(p=0.004),palliative prognostic index(PPI)(p=0.022)で統計学的に有意な差を認めた。生存時間分析では,respondersの生存期間中央値69(四分位範囲: 20～141)日とnon-respondersの生存期間中央値22(四分位範囲: 11～47)日で,生存期間に統計学的に有意な差(p=0.047)を認めた。PPI,PSは緩和ケアにおける赤血球輸血の効果予測因子として関連が示唆された。また,輸血効果と輸血後の生存期間に関連が示唆された。