内容紹介
Summary
A 77—year—old woman underwent preoperative chemoradiotherapy for rectal cancer in the Rb region(3 cm from the anal verge). The treatment regimen consisted of tegafur, gimeracil, and oteracil potassium(80 mg/m2/day, administered on days 1 to 5)and irinotecan(80 mg/m2, administered on day 1). A 1—week regimen was regarded a 1 course. In total, 4 courses were administered. Radiotherapy was administered with a margin of 1 cm around the tumor, with a daily dose of 1.8 Gy for 25 days. After treatment, evaluations were performed. Lower gastrointestinal endoscopy, barium enema examination, and computed tomography of the chest and abdomen were performed at 6 to 7 weeks, and a clinical complete response was observed. At the patient’s request, we decided to carefully follow—up the patient. Currently, 10 years 8 months after treatment, the patient still has a clinical complete response.
要旨
症例は77歳,女性。下部進行直腸癌(肛門縁から3 cm)の診断で術前化学放射線療法を施行した。治療レジメンはテガフール・ギメラシル・オテラシルカリウム(80 mg/m2/day,day 1～5),イリノテカン(80 mg/m2,day 1)を1週1コースとし,計4コース施行した。放射線治療は腫瘍から1 cmの距離までの範囲1.8 Gy/日×25日間の分割照射を行った。治療後評価を6～7週目に施行したところ,下部消化管内視鏡検査,注腸造影,胸腹部CT検査では臨床的完全奏効(clinical complete response:cCR)を認めた。患者の強い希望によりwatch and waitの方針となった。以降,厳重な経過観察を継続し,現在治療後10年8か月経過しているがcCR継続中である。
目次
A 77—year—old woman underwent preoperative chemoradiotherapy for rectal cancer in the Rb region(3 cm from the anal verge). The treatment regimen consisted of tegafur, gimeracil, and oteracil potassium(80 mg/m2/day, administered on days 1 to 5)and irinotecan(80 mg/m2, administered on day 1). A 1—week regimen was regarded a 1 course. In total, 4 courses were administered. Radiotherapy was administered with a margin of 1 cm around the tumor, with a daily dose of 1.8 Gy for 25 days. After treatment, evaluations were performed. Lower gastrointestinal endoscopy, barium enema examination, and computed tomography of the chest and abdomen were performed at 6 to 7 weeks, and a clinical complete response was observed. At the patient’s request, we decided to carefully follow—up the patient. Currently, 10 years 8 months after treatment, the patient still has a clinical complete response.
要旨
症例は77歳,女性。下部進行直腸癌(肛門縁から3 cm)の診断で術前化学放射線療法を施行した。治療レジメンはテガフール・ギメラシル・オテラシルカリウム(80 mg/m2/day,day 1～5),イリノテカン(80 mg/m2,day 1)を1週1コースとし,計4コース施行した。放射線治療は腫瘍から1 cmの距離までの範囲1.8 Gy/日×25日間の分割照射を行った。治療後評価を6～7週目に施行したところ,下部消化管内視鏡検査,注腸造影,胸腹部CT検査では臨床的完全奏効(clinical complete response:cCR)を認めた。患者の強い希望によりwatch and waitの方針となった。以降,厳重な経過観察を継続し,現在治療後10年8か月経過しているがcCR継続中である。