内容紹介
Summary
The patient was a 56—year—old woman. A modified LSG15(VCAP—AMP—VECP)regimen was initiated as the first—line treatment for acute adult T—cell leukemia/lymphoma. On day 13 from the initiation of the second course of chemotherapy, the onset of hand—foot syndrome(HFS)(hands:Grade 2;feet:Grade 1)occurred. Therefore, the administration of a heparin analog cream and betamethasone butyrate propionate ointment was initiated. On day 20 from the start of the second course of chemotherapy, the foot symptoms improved;however, hand symptoms deteriorated to Grade 3. Frequent use of alcohol—based hand hygiene products is associated with infection prevention during neutropenia, but was likely an exacerbating factor. The symptoms gradually improved after this was taken into consideration, and the usage was discontinued. At the start of the third course, the symptoms had improved to Grade 1, and chemotherapy was continued. On day 11, symptoms worsened(Grade 2). HFS management was performed similar to that in the second course, and symptoms improved again.
要旨
症例は56歳,女性。急性型成人T細胞白血病/リンパ腫に対する一次治療としてmodified LSG15(VCAP—AMP—VECP)を開始した。化学療法2コース目開始13日目から手足症候群(hand—foot syndrome:HFS)(手:Grade 2,足:Grade 1)が出現した。このためヘパリン類似物質油性クリーム,ベタメタゾン酪酸エステルプロピオン酸エステル軟膏を開始した。2コース目開始20日目に足の症状は軽快したものの,手の症状はGrade 3に増悪した。好中球減少時の感染予防のため頻回なアルコールによる手指衛生を行っていたが,これがHFSの増悪因子であることを考慮し中止すると徐々に症状は改善した。3コース目開始時点ではGrade 1まで改善し,化学療法を続行すると3コース目開始11日目に症状はGrade 2に再増悪した。このため2コース目と同様の治療を行い,症状は再度改善した。
目次
The patient was a 56—year—old woman. A modified LSG15(VCAP—AMP—VECP)regimen was initiated as the first—line treatment for acute adult T—cell leukemia/lymphoma. On day 13 from the initiation of the second course of chemotherapy, the onset of hand—foot syndrome(HFS)(hands:Grade 2;feet:Grade 1)occurred. Therefore, the administration of a heparin analog cream and betamethasone butyrate propionate ointment was initiated. On day 20 from the start of the second course of chemotherapy, the foot symptoms improved;however, hand symptoms deteriorated to Grade 3. Frequent use of alcohol—based hand hygiene products is associated with infection prevention during neutropenia, but was likely an exacerbating factor. The symptoms gradually improved after this was taken into consideration, and the usage was discontinued. At the start of the third course, the symptoms had improved to Grade 1, and chemotherapy was continued. On day 11, symptoms worsened(Grade 2). HFS management was performed similar to that in the second course, and symptoms improved again.
要旨
症例は56歳,女性。急性型成人T細胞白血病/リンパ腫に対する一次治療としてmodified LSG15(VCAP—AMP—VECP)を開始した。化学療法2コース目開始13日目から手足症候群(hand—foot syndrome:HFS)(手:Grade 2,足:Grade 1)が出現した。このためヘパリン類似物質油性クリーム,ベタメタゾン酪酸エステルプロピオン酸エステル軟膏を開始した。2コース目開始20日目に足の症状は軽快したものの,手の症状はGrade 3に増悪した。好中球減少時の感染予防のため頻回なアルコールによる手指衛生を行っていたが,これがHFSの増悪因子であることを考慮し中止すると徐々に症状は改善した。3コース目開始時点ではGrade 1まで改善し,化学療法を続行すると3コース目開始11日目に症状はGrade 2に再増悪した。このため2コース目と同様の治療を行い,症状は再度改善した。