内容紹介
Summary
Most primary gastric mucosa—associated lymphoid tissue(MALT)lymphomas are associated with a chronic Helicobacter pylori(H. pylori)infection. The eradication of H. pylori is the first—line treatment for H. pylori—positive cases with early—stage disease. In addition, successful treatment of H. pylori—negative early stage MALT lymphomas by eradication has been reported in several small cases series. However, the association of primary gastrointestinal MALT lymphomas with H. pylori in areas other than the stomach is not clear, and the efficacy of eradication therapy for these patients has not been established. We performed H. pylori eradication therapy for H. pylori—negative cecum MALT lymphoma. Three months later, a histopathological examination showed no evidence of MALT lymphoma, and the patient was classified as being in remission. So far, the patient has been in remission for 1 year and 6 months. Our case is the first report of successfully treating H. pylori—negative cecum MALT lymphoma with eradication therapy.
要旨
胃原発mucosa—associated lymphoid tissue(MALT)リンパ腫はHelicobacter pylori(H. pylori)との関連が明らかになっており,限局期のH. pylori陽性症例では除菌療法が第一選択となっている。また,H. pylori陰性例に対してもその有効性を示す報告がある。一方,胃以外の消化管原発MALTリンパ腫のH. pyloriとの関連性は明らかではなく,除菌療法の有効性については確立されていない。今回,H. pylori陰性の虫垂原発MALTリンパ腫に対してH. pylori除菌療法を施行し,1年6か月間寛解を維持している症例を経験した。これは,H. pylori陰性の虫垂原発MALTリンパ腫に対しても除菌療法が有効であることを示した初めての報告である。
目次
Most primary gastric mucosa—associated lymphoid tissue(MALT)lymphomas are associated with a chronic Helicobacter pylori(H. pylori)infection. The eradication of H. pylori is the first—line treatment for H. pylori—positive cases with early—stage disease. In addition, successful treatment of H. pylori—negative early stage MALT lymphomas by eradication has been reported in several small cases series. However, the association of primary gastrointestinal MALT lymphomas with H. pylori in areas other than the stomach is not clear, and the efficacy of eradication therapy for these patients has not been established. We performed H. pylori eradication therapy for H. pylori—negative cecum MALT lymphoma. Three months later, a histopathological examination showed no evidence of MALT lymphoma, and the patient was classified as being in remission. So far, the patient has been in remission for 1 year and 6 months. Our case is the first report of successfully treating H. pylori—negative cecum MALT lymphoma with eradication therapy.
要旨
胃原発mucosa—associated lymphoid tissue(MALT)リンパ腫はHelicobacter pylori(H. pylori)との関連が明らかになっており,限局期のH. pylori陽性症例では除菌療法が第一選択となっている。また,H. pylori陰性例に対してもその有効性を示す報告がある。一方,胃以外の消化管原発MALTリンパ腫のH. pyloriとの関連性は明らかではなく,除菌療法の有効性については確立されていない。今回,H. pylori陰性の虫垂原発MALTリンパ腫に対してH. pylori除菌療法を施行し,1年6か月間寛解を維持している症例を経験した。これは,H. pylori陰性の虫垂原発MALTリンパ腫に対しても除菌療法が有効であることを示した初めての報告である。